Document Type
Article
Publication Date
11-16-2016
Publication Title
Biomedical Optics Express
Department
Thayer School of Engineering
Abstract
Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden. The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival.
DOI
10.1364/BOE.7.005129
Dartmouth Digital Commons Citation
Jermyn, Michael; Desroches, Joannie; Mercier, Jeanne; and St-Arnaud, Karl, "Raman Spectroscopy Detects Distant Invasive Brain Cancer Cells Centimeters beyond MRI Capability in Humans" (2016). Dartmouth Scholarship. 1701.
https://digitalcommons.dartmouth.edu/facoa/1701