Overexpression of Core-Binding Factor Alpha (CBF Alpha) Reverses Cellular Transformation by the CBF Beta-Smooth Muscle Myosin Heavy Chain Chimeric Oncoprotein.
A Hajra;P Liu;N Speck;F Collins
Abstract
A fusion between the transcription factor core-binding factor beta (CBF beta; also known as PEBP2 beta) and the tail region of smooth muscle myosin heavy chain (SMMHC) is generated by an inversion of chromosome 16 [inv(16) (p13q22)] associated with the M4Eo subtype of acute myeloid leukemia. We have previously shown that this CBF beta-SMMHC chimeric protein can transform NIH 3T3 cells and that this process requires regions of the chimeric protein necessary for association with the CBF alpha subu
This paper has been withdrawn.