Document Type
Article
Publication Date
8-31-2012
Publication Title
Biomedical Optics Express
Department
Thayer School of Engineering
Abstract
The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue- simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast.
DOI
10.1364/BOE.3.002339
Original Citation
Mastanduno MA, Jiang S, Diflorio-Alexander R, Pogue BW, Paulsen KD. Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy. Biomed Opt Express. 2012 Oct 1;3(10):2339-52. doi: 10.1364/BOE.3.002339. Epub 2012 Aug 31. PMID: 23082277; PMCID: PMC3470001.
Dartmouth Digital Commons Citation
Mastanduno, Michael A.; Jiang, Shudong; DiFlorio-Alexander, Roberta; Pogue, Brian W.; and Paulsen, Keith, "Automatic And Robust Calibration of Optical Detector Arrays for Biomedical Diffuse Optical Spectroscopy" (2012). Dartmouth Scholarship. 2556.
https://digitalcommons.dartmouth.edu/facoa/2556
