Document Type
Article
Publication Date
1-1-2000
Publication Title
The Journal of Experimental Medicine
Department
Geisel School of Medicine
Abstract
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.
DOI
10.1084/jem.191.2.381
Original Citation
Garceau N, Kosaka Y, Masters S, Hambor J, Shinkura R, Honjo T, Noelle RJ. Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. J Exp Med. 2000 Jan 17;191(2):381-6. doi: 10.1084/jem.191.2.381. PMID: 10637282; PMCID: PMC2195761.
Dartmouth Digital Commons Citation
Garceau, Norman; Kosaka, Yoko; Masters, Sally; Hambor, John; Shinkura, Reiko; Honjo, Tasuko; and Noelle, Randolph J., "Lineage-Restricted Function of Nuclear Factor KappaB-Inducing Kinase (NIK) in Transducing Signals Via CD40." (2000). Dartmouth Scholarship. 2890.
https://digitalcommons.dartmouth.edu/facoa/2890
