Document Type
Article
Publication Date
10-5-2009
Publication Title
The Journal of Experimental Medicine
Department
Geisel School of Medicine
Abstract
During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues.
DOI
10.1084/jem.20090805
Dartmouth Digital Commons Citation
Kunder, Christian A.; St. John, Ashley L.; Li, Guojie; Leong, Kam W.; Berwin, Brent; Staats, Herman F.; and Abraham, Soman N., "Mast Cell–Derived Particles Deliver Peripheral Signals to Remote Lymph Nodes" (2009). Dartmouth Scholarship. 2908.
https://digitalcommons.dartmouth.edu/facoa/2908
