Document Type
Article
Publication Date
2015
Publication Title
PLoS Pathogens
Abstract
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The Ras1-Cyr1-PKA pathway is a major regulator of C. albicans morphogenesis as well as biofilm formation and white-opaque switching. Previous studies have shown that hyphal growth is strongly repressed by mitochondrial inhibitors. Here, we s
DOI
10.1371/journal.ppat.1005133
Recommended Citation
Grahl, Nora; Demers, Elora G.; Lindsay, Allia K.; and Harty, Colleen E., "Mitochondrial Activity and Cyr1 are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways" (2015). Open Dartmouth: Faculty Open Access Articles. 2931.
https://digitalcommons.dartmouth.edu/facoa/2931