Scattering phase Function Spectrum Makes Reflectance Spectrum Measured from Intralipid phantoms and Tissue Sensitive to the Device Detection Geometry

Authors

S. C. Kanick, Dartmouth College
V. Krishnaswamy, Dartmouth College
U. A. Gamm, Erasmus Medical CenterFollow
H. J.C.M Sterenborg, Erasmus Medical Center
D. J. Robinson, Erasmus Medical Center
A. Amelink, Erasmus Medical CenterFollow
B. W. Pogue, Dartmouth College

Document Type

Article

Publication Date

4-24-2012

Publication Title

Biomedical Optics Express

Department

Thayer School of Engineering

Abstract

Reflectance spectra measured in Intralipid (IL) close to the source are sensitive to wavelength -dependent changes in reduced scattering coefficient (μ_s′)and scattering phase function (PF). Experiments and simulations were performed using device designs with either single or separate optical fibers for delivery and collection of light in varying concentrations of IL. Spectral reflectance is not consistentl y linear with varying IL concentration, with PF -dependent effects observed for single fiber devices with diameters smaller than ten transport lengths and for separate source- detector devices that collected light at less than half of a transport length from the source. Similar effects are thought to be seen in tissue, limiting the ability to quantitatively compare spectra from different devices without compensation.

DOI

10.1364/BOE.3.001086

Dartmouth Digital Commons Citation

Kanick, S. C.; Krishnaswamy, V.; Gamm, U. A.; Sterenborg, H. J.C.M; Robinson, D. J.; Amelink, A.; and Pogue, B. W., "Scattering phase Function Spectrum Makes Reflectance Spectrum Measured from Intralipid phantoms and Tissue Sensitive to the Device Detection Geometry" (2012). Dartmouth Scholarship. 3180.
https://digitalcommons.dartmouth.edu/facoa/3180