CD4(+) T Cells Tolerized Ex Vivo to Host Alloantigen by Anti-CD40 Ligand (CD40L:CD154) Antibody Lose their Graft-Versus-Host Disease Lethality Capacity but Retain Nominal Antigen Responses.

Authors

Bruce R. Blazar, University of Minnesota
Patricia A. Taylor, University of Minnesota
Randolph J. Noelle, Dartmouth College
Daniel A. Vallera, University of Minnesota

Document Type

Article

Publication Date

8-1-1998

Publication Title

Journal of Clinical Investigation

Department

Geisel School of Medicine

Abstract

A major goal of the transplant field is to tolerize donor T cells to prevent graft-versus-host disease (GVHD) (1). We describe an ex vivo approach in which the blockade of CD40 ligand (CD40L:CD154):CD40 interactions, a pathway required for optimal T cell expansion, induces donor CD4(+) T cells to become tolerant to host alloantigens (2). High doses of tolerized cells did not cause GVHD lethality in vivo. T cells had intact responses to antigens not present during tolerization. Tolerance was long lived and not readily reversible in vivo. These data have significant implications for the use of tolerization approaches to prevent human GVHD.

DOI

10.1172/JCI3741

Original Citation

Blazar BR, Taylor PA, Noelle RJ, Vallera DA. CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses. J Clin Invest. 1998;102(3):473-482. doi:10.1172/JCI3741

Dartmouth Digital Commons Citation

Blazar, Bruce R.; Taylor, Patricia A.; Noelle, Randolph J.; and Vallera, Daniel A., "CD4(+) T Cells Tolerized Ex Vivo to Host Alloantigen by Anti-CD40 Ligand (CD40L:CD154) Antibody Lose their Graft-Versus-Host Disease Lethality Capacity but Retain Nominal Antigen Responses." (1998). Dartmouth Scholarship. 3627.
https://digitalcommons.dartmouth.edu/facoa/3627