Hybrid Photomultiplier Tube and Photodiode Parallel Detection Array for Wideband Optical Spectroscopy of the Breast Guided by Magnetic Resonance Imaging

Authors

Fadi El-Ghussein, Dartmouth CollegeFollow
Michael A. Mastanduno, Dartmouth College
Shudong Jiang, Dartmouth College
Brian W. Pogue, Dartmouth College
Keith D. Paulsen, Dartmouth College

Document Type

Article

Publication Date

8-26-2014

Publication Title

Journal of Biomedical Optics

Department

Thayer School of Engineering

Abstract

A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges of the detected signal are 10⁵ and 10⁶ for PMT and PD detectors, respectively. Compared to the previous detection system, the SNR ratio of frequency-domain detection was improved by nearly 10³ through the addition of an RF amplifier and the utilization of programmable gain. The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans.

DOI

10.1117/1.JBO.19.1.011010

Dartmouth Digital Commons Citation

El-Ghussein, Fadi; Mastanduno, Michael A.; Jiang, Shudong; Pogue, Brian W.; and Paulsen, Keith D., "Hybrid Photomultiplier Tube and Photodiode Parallel Detection Array for Wideband Optical Spectroscopy of the Breast Guided by Magnetic Resonance Imaging" (2014). Dartmouth Scholarship. 3648.
https://digitalcommons.dartmouth.edu/facoa/3648