Antimicrobial Agents and Chemotherapy
Previous articles reported that beta-lactam antibiotics increase the expression of Staphylococcus aureus Panton-Valentine leukocidin (PVL) by activating its transcription. We investigated the mechanisms underlying the inductor effect of beta-lactams on PVL expression by determining targets and regulatory pathways possibly implicated in this process. We measured PVL production in the presence of oxacillin (nonselective), imipenem (penicillin-binding protein 1 [PBP1] selective), cefotaxime (PBP2 s
Dumitrescu, Oana; Choudhury, Priya; Boisset, Sandrine; Badiou, Cedric; Bes, Michele; Benito, Yvonne; Wolz, Christiane; Vandenesch, Francois; Etienne, Jerome; and Cheung, Ambrose L., "β-Lactams Interfering with PBP1 Induce Panton-Valentine Leukocidin Expression by Triggering sarA and rot Global Regulators of Staphylococcus aureus" (2011). Open Dartmouth: Faculty Open Access Articles. 470.