Document Type

Article

Publication Date

5-15-2003

Publication Title

Arthritis Research and Therapy

Department

Geisel School of Medicine

Abstract

Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express

DOI

10.1186/ar778

Original Citation

Fairhurst, AM., Connolly, J.E., Hintz, K.A. et al. Regulation and localization of endogenous human tristetraprolin. Arthritis Res Ther 5, R214 (2003). https://doi.org/10.1186/ar778

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