Multifactor Dimensionality Reduction Analysis Identifies Specific Nucleotide Patterns Promoting Genetic Polymorphisms

Authors

Eric Arehart, Dartmouth College
Scott Gleim, Dartmouth College
Bill White, Dartmouth College
John Hwa, Dartmouth College
Jason H. Moore, Dartmouth College

Document Type

Article

Publication Date

3-30-2009

Publication Title

BioData Mining

Department

Geisel School of Medicine

Additional Department

Department of Biological Sciences

Abstract

The fidelity of DNA replication serves as the nidus for both genetic evolution and genomic instability fostering disease. Single nucleotide polymorphisms (SNPs) constitute greater than 80% of the genetic variation between individuals. A new theory regarding DNA replication fidelity has emerged in which selectivity is governed by base-pair geometry through interactions between the selected nucleotide, the complementary strand, and the polymerase active site. We hypothesize that specific nucleotide combinations in the flanking regions of SNP fragments are associated with mutation.

DOI

10.1186/1756-0381-2-2

Original Citation

Arehart E, Gleim S, White B, Hwa J, Moore JH. Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms. BioData Min. 2009 Mar 30;2(1):2. doi: 10.1186/1756-0381-2-2. PMID: 19331672; PMCID: PMC2669078.

Dartmouth Digital Commons Citation

Arehart, Eric; Gleim, Scott; White, Bill; Hwa, John; and Moore, Jason H., "Multifactor Dimensionality Reduction Analysis Identifies Specific Nucleotide Patterns Promoting Genetic Polymorphisms" (2009). Dartmouth Scholarship. 551.
https://digitalcommons.dartmouth.edu/facoa/551