Document Type
Article
Publication Date
5-9-2015
Publication Title
Biotechnology for Biofuels
Department
Thayer School of Engineering
Abstract
The liberation of acetate from hemicellulose negatively impacts fermentations of cellulosic biomass, limiting the concentrations of substrate that can be effectively processed. Solvent-producing bacteria have the capacity to convert acetate to the less toxic product acetone, but to the best of our knowledge, this trait has not been transferred to an organism that produces ethanol at high yield. We have engineered a five-step metabolic pathway to convert acetic acid to acetone in the thermophilic anaerobe Thermoanaerobacterium saccharolyticum.
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DOI
10.1186/s13068-015-0257-4
Dartmouth Digital Commons Citation
Shaw, A Joe; Miller, Bethany B.; Rogers, Stephen R.; Kenealy, William Robert; Meola, Alex; Bhandiwad, Ashwini; Sillers, W Ryan; Shikhare, Indraneel; Hogsett, David; and Herring, Christopher, "Anaerobic Detoxification of Acetic Acid in a Thermophilic Ethanologen" (2015). Dartmouth Scholarship. 560.
https://digitalcommons.dartmouth.edu/facoa/560