Document Type

Article

Publication Date

4-9-2010

Publication Title

BMC Bioinformatics

Department

Department of Computer Science

Abstract

To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived from the foreign protein. Thus, developing minimal-epitope variants represents a powerful approach to deimmunizing protein therapeutics. Critically, mutations selected to reduce immunogenicity must not interfere with the protein's therapeutic activity.

DOI

10.1186/1471-2105-11-180

Original Citation

Parker AS, Zheng W, Griswold KE, Bailey-Kellogg C. Optimization algorithms for functional deimmunization of therapeutic proteins. BMC Bioinformatics. 2010 Apr 9;11:180. doi: 10.1186/1471-2105-11-180. PMID: 20380721; PMCID: PMC2873530.

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