Document Type
Article
Publication Date
11-10-2015
Publication Title
BioMed Central Cancer
Department
Geisel School of Medicine
Additional Department
Thayer School of Engineering
Abstract
USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months of age. These tumors are leiomyosarcomas and thus represent a new murine model for this disease.
DOI
10.1186/s12885-015-1883-8
Dartmouth Digital Commons Citation
Chinyengetere, Fadzai; Sekula, David J.; Lu, Yun; Giustini, Andrew J.; Sanglikar, Aarti; Kawakami, Masanori; and Ma, Tian, "Mice Null for the Deubiquitinase USP18 Spontaneously Develop Leiomyosarcomas" (2015). Dartmouth Scholarship. 576.
https://digitalcommons.dartmouth.edu/facoa/576