Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma
Document Type
Article
Publication Date
5-1-2017
Publication Title
Clinical Cancer Research
Department
Thayer School of Engineering
Additional Department
Geisel School of Medicine
Abstract
While extent of tumor resection is an important predictor of outcome in glioma, margin delineation remains challenging due to lack of inherent contrast between tumor and normal parenchyma. Fluorescence-guided surgery is promising for its ability to enhance contrast through exogenous fluorophores; however, the specificity and sensitivity of the underlying contrast mechanism and tumor delivery and uptake vary widely across approved and emerging agents.
DOI
10.1158/1078-0432.CCR-16-1400
Original Citation
Elliott JT, Marra K, Evans LT, Davis SC, Samkoe KS, Feldwisch J, Paulsen KD, Roberts DW, Pogue BW. Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma. Clin Cancer Res. 2017 May 1;23(9):2203-2212. doi: 10.1158/1078-0432.CCR-16-1400. Epub 2016 Oct 31. PMID: 27799250; PMCID: PMC5411329.
Dartmouth Digital Commons Citation
Elliot, Jonathon T.; Marra, Kayla; Evans, Linton T.; Davis, Scott C.; Samkoe, Kimberly; Feldwisch, Joachim; Paulsen, Keith D.; Roberts, David W.; and Pogue, Brian W., "Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma" (2017). Dartmouth Scholarship. 72.
https://digitalcommons.dartmouth.edu/facoa/72
