Title

Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma

Document Type

Article

Publication Date

5-1-2017

Publication Title

Clinical Cancer Research

Department

Thayer School of Engineering

Additional Department

Geisel School of Medicine

Abstract

While extent of tumor resection is an important predictor of outcome in glioma, margin delineation remains challenging due to lack of inherent contrast between tumor and normal parenchyma. Fluorescence-guided surgery is promising for its ability to enhance contrast through exogenous fluorophores; however, the specificity and sensitivity of the underlying contrast mechanism and tumor delivery and uptake vary widely across approved and emerging agents.

DOI

10.1158/1078-0432.CCR-16-1400

Original Citation

Elliott JT, Marra K, Evans LT, Davis SC, Samkoe KS, Feldwisch J, Paulsen KD, Roberts DW, Pogue BW. Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma. Clin Cancer Res. 2017 May 1;23(9):2203-2212. doi: 10.1158/1078-0432.CCR-16-1400. Epub 2016 Oct 31. PMID: 27799250; PMCID: PMC5411329.

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