Document Type

Article

Publication Date

2-22-2010

Publication Title

Critical Care

Department

Geisel School of Medicine

Abstract

Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dysregulation of the microvasculature and with organ failure in clinical severe sepsis.

DOI

10.1186/cc8887

Original Citation

Doerschug KC, Delsing AS, Schmidt GA, Ashare A. Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis. Crit Care. 2010;14(1):R24. doi: 10.1186/cc8887. Epub 2010 Feb 22. PMID: 20175923; PMCID: PMC2875539.

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