Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer
Document Type
Article
Publication Date
9-13-2016
Publication Title
British Journal of Cancer
Department
Thayer School of Engineering
Additional Department
Geisel School of Medicine
Abstract
Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) provides selective uptake and conversion of ALA into protoporphyrin IX (PpIX) in actinic keratosis and squamous cell carcinoma, yet large response variations in effect are common between individuals. The aim of this study was to compare pre-treatment strategies that increase the therapeutic effect, including fractionated light delivery during PDT (fPDT) and use of iron chelator desferrioxamine (DFO), separately and combined.
DOI
10.1038/bjc.2016.267
Dartmouth Digital Commons Citation
Ribeiro de Souza, Ana Luiza; Marra, Kayla; Gunn, Jason; Samkoe, Kimberly; Kanick, Stephen; Davis, Scott; Chapman, M Shane; Maytin, Edward; Hasan, Tayyaba; and Pogue, Brian, "Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer" (2016). Dartmouth Scholarship. 73.
https://digitalcommons.dartmouth.edu/facoa/73
