Document Type

Article

Publication Date

1-2005

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

DOI

10.1128/IAI.73.1.617-621.2005

Original Citation

Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 2005 Jan;73(1):617-21. doi: 10.1128/IAI.73.1.617-621.2005. PMID: 15618203; PMCID: PMC538931.

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