Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

Authors

Michelle N. Kelly, Louisiana State University Health Sciences Center New Orleans
Jay K. Kolls, University of Pittsburgh
Kyle Happel, Louisiana State University Health Sciences Center New Orleans
Joseph D. Schwartzman, Dartmouth College

Document Type

Article

Publication Date

1-2005

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

DOI

10.1128/IAI.73.1.617-621.2005

Original Citation

Kelly MN, Kolls JK, Happel K, Schwartzman JD, Schwarzenberger P, Combe C, Moretto M, Khan IA. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 2005 Jan;73(1):617-21. doi: 10.1128/IAI.73.1.617-621.2005. PMID: 15618203; PMCID: PMC538931.

Dartmouth Digital Commons Citation

Kelly, Michelle N.; Kolls, Jay K.; Happel, Kyle; and Schwartzman, Joseph D., "Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection" (2005). Dartmouth Scholarship. 953.
https://digitalcommons.dartmouth.edu/facoa/953