Impacts of sarA and agr in Staphylococcus aureus Strain Newman on Fibronectin-Binding Protein A Gene Expression and Fibronectin Adherence Capacity In Vitro and in Experimental Infective Endocarditis

Authors

Yan-Qiong Xiong, University of California, Los Angeles
Arnold S. Bayer, University of California, Los AngelesFollow
Michael R. Yeaman, University of California, Los Angeles
Willem van Wamel, Utrecht University
Adhar C. Manna, Dartmouth College
Ambrose L. Cheung, Dartmouth CollegeFollow

Document Type

Article

Publication Date

3-2004

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

We investigated the impacts of sarA and agr on fnbA expression and fibronectin-binding capacity in Staphylococcus aureus in vitro and in experimental endocarditis. Although sarA up-regulated and agr down-regulated both fnbA expression and fibronectin binding in vitro and in vivo, fnbA expression was positively regulated in the absence of both global regulators. Thus, additional regulatory loci contribute to fnbA regulation and fibronectin-binding capacities in S. aureus.

DOI

10.1128/IAI.72.3.1832-1836.2004

Dartmouth Digital Commons Citation

Xiong, Yan-Qiong; Bayer, Arnold S.; Yeaman, Michael R.; van Wamel, Willem; Manna, Adhar C.; and Cheung, Ambrose L., "Impacts of sarA and agr in Staphylococcus aureus Strain Newman on Fibronectin-Binding Protein A Gene Expression and Fibronectin Adherence Capacity In Vitro and in Experimental Infective Endocarditis" (2004). Dartmouth Scholarship. 961.
https://digitalcommons.dartmouth.edu/facoa/961