Document Type
Article
Publication Date
3-2004
Publication Title
Infection and Immunity
Department
Geisel School of Medicine
Abstract
We investigated the impacts of sarA and agr on fnbA expression and fibronectin-binding capacity in Staphylococcus aureus in vitro and in experimental endocarditis. Although sarA up-regulated and agr down-regulated both fnbA expression and fibronectin binding in vitro and in vivo, fnbA expression was positively regulated in the absence of both global regulators. Thus, additional regulatory loci contribute to fnbA regulation and fibronectin-binding capacities in S. aureus.
DOI
10.1128/IAI.72.3.1832-1836.2004
Dartmouth Digital Commons Citation
Xiong, Yan-Qiong; Bayer, Arnold S.; Yeaman, Michael R.; van Wamel, Willem; Manna, Adhar C.; and Cheung, Ambrose L., "Impacts of sarA and agr in Staphylococcus aureus Strain Newman on Fibronectin-Binding Protein A Gene Expression and Fibronectin Adherence Capacity In Vitro and in Experimental Infective Endocarditis" (2004). Dartmouth Scholarship. 961.
https://digitalcommons.dartmouth.edu/facoa/961
Included in
Cardiovascular Diseases Commons, Infectious Disease Commons, Medical Microbiology Commons