Document Type

Article

Publication Date

2-2001

Publication Title

Infection and Immunity

Department

Geisel School of Medicine

Abstract

The expression of virulence determinants in Staphylococcus aureus is controlled by global regulatory loci (e.g., sar and agr). The sar locus is composed of three overlapping transcripts (sar P1, P3, and P2 transcripts from P1, P3, and P2 promoters, respectively), all encoding the 372-bp sarA gene. The level of SarA, the major regulatory protein, is partially controlled by the differential activation of sar promoters. We previously partially purified a ∼12 kDa protein with a DNA-specific column

DOI

10.1128/IAI.69.2.885-896.2001

Original Citation

Manna A, Cheung AL. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus. Infect Immun. 2001;69(2):885-896. doi:10.1128/IAI.69.2.885-896.2001

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