Author ORCID Identifier

https://orcid.org/0000-0002-0746-7397

Date of Award

Fall 11-14-2025

Document Type

Thesis (Ph.D.)

Department or Program

Chemistry

First Advisor

Wenlin Zhang

Second Advisor

Chenfeng Ke

Abstract

Designing organic materials with precisely controlled functions remains a central challenge in chemistry and materials science. Two important classes of organic materials are polymer networks and crystalline frameworks. Although they exhibit fundamentally different morphologies and synthesis routes, they share some structural principles that govern their behaviors. This thesis explores two of these key principles: crystallinity and topology, and their roles in controlling structure–property relationships.

To address the challenge of achieving high crystallinity in stable organic frameworks, we developed a synthetic strategy to construct hydrogen-bonded crosslinked organic frameworks (H\textsubscript{C}OFs). These materials are formed by assembly of hydrogen-bonding motifs followed by single-crystal-to-single-crystal covalent crosslinking, enabling the combination of large pores, enhanced stability, and high single-crystallinity. The unique topology formed by hydrogen bonding and covalent crosslinking endows the resulting frameworks with the abililty to retain long-range order during guest-induced expansion/contraction. This work in Chapter 2 establishes a platform for creating dynamic crystalline frameworks with tunable porosity and robustness.

Crystallinity and topology in polymer systems were investigated through the lens of entanglements and interfacial compatibilization. Using coarse-grained molecular dynamics simulations, we examined how interfacial incompatibility and block copolymer compatibilizers affect crystallization and mechanical response (Chapters 3–4). The results show that entanglement density and chain architecture play decisive roles in determining stress transmission and interfacial strength, while block copolymers can modulate both local crystallinity and failure mechanisms by bridging interfaces and introducing topological constraints.

Finally, we initiated the development of a united-atom simulation framework to model the crystallization of recyclable, polyethylene-mimic aliphatic polyesters (Chapter 5). Preliminary studies reveal the relationship between layer packing and chain architecture, suggesting a direct link between molecular structure and mesoscale ordering. Ongoing work aims to establish structure–property correlations for these sustainable semicrystalline polymers.

Together, these studies demonstrate that crystallinity and topology are unifying design principles for both organic frameworks and polymer networks. By demonstrating how molecular packing and connectivity control structure and dynamics across these systems, this thesis provides insight that may inform the rational design of multifunctional organic materials.

Original Citation

Samanta J, Zhang Y, Zhang M, Chen, A. Ke, C. Single-crystalline hydrogen-bonded crosslinked organic frameworks and their dynamic guest sorption. Acc. Mater. Res., 2022, 3(11): 1186-1200.

Zhang, Y.; Liang, R.; Atterberry, B.; Li, F.; Staples, R.; Zhang, J.; Samanta, J.; Rossini, A.; Ke, C.; Ultra-dynamic Isoreticularly Expanded Porous Organic Crystals J. Am. Chem. Soc. 146.22, 2024: 15525-15537

Zhang, Y.; Zhang, W.; Effects of Block Copolymer Compatibilizers and Interfacial Entanglements on Strengthening Immiscible Glassy Polymer Blends Macromolecules, 58.5 2025: 2484–2493

Available for download on Friday, November 19, 2027

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