Effects of In Utero Alcohol Exposure on Migration of Postmitotic Projection Neurons in Somatosensory Cortex and Medial Prefrontal Cortex in Postnatal Day 0 Mice

Authors

• Erika Huston, Dartmouth CollegeFollow
• Hermes H. Yeh, Dartmouth CollegeFollow
• Pamela W.L. Yeh, Dartmouth CollegeFollow

Files

Student Class

2026

Student Affiliation

Independent Study

First Advisor

Hermes Yeh

First Advisor Department

Geisel School of Medicine

Second Advisor

Pam Yeh

Second Advisor Department

Geisel School of Medicine

Abstract

Delatour et al. concluded that TBR1-expressing cell bands were diffused due to pre-natal ethanol exposure in embryonic day 16.5 mice. I hypothesized that this effect would also be observed in post-natal day 0 mice. Calculating the length of the lower cortical plate compared to the entire cortical plate, comparing the fluorescence intensity of the upper and lower cortical plate, and mapping the progression of fluorescence intensity through the cortex were methods used to evaluate this hypothesis. With consideration for the limited sample size, significant results were not obtained. However, effect sizes for the overall and progressive somatosensory cortex fluorescence intensity comparison as well as the overall medial prefrontal cortex fluorescence intensity comparison were found to be large. This indicates that future studies with more litters may find significant results.

Publication Date

Winter 2026

Dartmouth Digital Commons Citation

Huston, Erika; Yeh, Hermes H.; and Yeh, Pamela W.L., "Effects of In Utero Alcohol Exposure on Migration of Postmitotic Projection Neurons in Somatosensory Cortex and Medial Prefrontal Cortex in Postnatal Day 0 Mice" (2026). Wetterhahn Science Symposium Posters. 4.
https://digitalcommons.dartmouth.edu/wetterhahnsymposiumposters/4