This collection contains works by faculty from the Geisel School of Medicine.

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Submissions from 1997

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Dissection of a Circadian Oscillation into Discrete Domains, Martha W. Merrow, Norman Y. Garceau, and Jay C. Dunlap

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Cell Signaling Pathways Elicited by Asbestos, B T. Mossman, S Faux, Y Janssen, L A. Jimenez, Cynthia Timblin, Christine Zanella, Jonathan Goldberg, Eric Walsh, Aaron Barchowsky, and Kevin Driscoll

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Phosphorylation Regulates the Assembly of Numa in a Mammalian Mitotic Extract, Alejandro Saredi, Louisa Howard, and Duane A. Compton

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Cyclic AMP and its Receptor Protein Negatively Regulate the Coordinate Expression of Cholera Toxin and Toxin-Coregulated Pilus in Vibrio Cholerae, Karen Skorupski and Ronald K. Taylor

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I2B is a Small Cytosolic Protein that Participates in Vacuole Fusion, Paul Slusarewicz, Zuoyu Xu, Kimberly Seefeld, Albert Haas, and William T. Wickner

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Where do Elderly Veterans Obtain Care for Acute Myocardial Infarction: Department of Veterans Affairs or Medicare?, S M. Wright, J Daley, E S. Fisher, and G E. Thibault

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A Novel Polymorphism of FcgammaRIIIa (CD16) Alters Receptor Function and Predisposes to Autoimmune Disease, Jianming Wu, Jeffrey C. Edberg, Patricia B. Redecha, Vipin Bansal, Paul M. Guyre, Kimberly Coleman, Jane E. Salmon, and Robert P. Kimberly

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A Heterodimer of Thioredoxin and IB2 Cooperates with Sec18p (NSF) to Promote Yeast Vacuole Inheritance, Zuoyu Xu, Andreas Mayer, Eric Muller, and William Wickner

Submissions from 1996

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Activation of the Human Thymidine Kinase (TK) Promoter by Simian Virus 40 Large T Antigen Requires Both the T Antigen pRb Family-binding Domain and TK Promoter Sequences Resembling E2F-binding Sites., Michelle M. Anderson, Jun Chen, Charles N. Cole, and Susan E. Conrad

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Distinct Cis-acting Elements Mediate Clock, Light, and Developmental Regulation of the Neurospora Crassa Eas (ccg-2) Gene., Deborah Bell-Pedersen, Jay C. Dunlap, and Jennifer J. Loros

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Circadian Clock-Controlled Genes Isolated from Neurospora Crassa are Late Night- To Early Morning-Specific, Deborah Bell-Pedersen, Mari L. Shinohara, Jennifer J. Loros, and Jay C. Dunlap

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Toxoplasma gondii-induced Immune Suppression by Human Peripheral Blood Monocytes: Role of Gamma Interferon., Jacqueline Y. Channon and Lloyd H. Kasper

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Measuring Hospital Use without Claims: A Comparison of Patient and Provider Reports., R E. Clark, S K. Ricketts, and G J. McHugo

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Cloning of the Mammalian Type II Iodothyronine Deiodinase. A Selenoprotein Differentially Expressed and Regulated in Human and Rat Brain and Other Tissues., Walburga Croteau, Jennifer C. Davey, Valerie Anne Galton, and Donald L. St Germain

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The Product of the Saccharomyces Cerevisiae RSS1 Gene, Identified as a High-Copy Suppressor of the Rat7-1 Temperature-Sensitive Allele of the RAT7/NUP159 Nucleoporin, is Required for Efficient mRNA Export, Veronica Del Priore, Christine A. Snay, Andre Bahr, and Charles N. Cole

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Differential Expression of the ToxR Regulon in Classical and E1 Tor Biotypes of Vibrio cholerae is Due to Biotype-Specific Control over toxT Expression., Victor J. DiRita, Melody Neely, Ronald K. Taylor, and Paul M. Bruss

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Antisense Oligodeoxynucleotide Inhibition of a Swelling-Activated Cation Channel in Osteoblast-Like Osteosarcoma Cells., Randall L. Duncan, Neil Kizer, Elizabeth L. Barry, Peter P A Friedman, and Keith A. Hruska

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Reversal of Cell Fate Determination in Caenorhabditis Elegans Vulval Development, Susan Euling and Victor Ambros

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Opposing Motor Activities are Required for the Organization of the Mammalian Mitotic Spindle Pole, Tirso Gaglio, Alejandro Saredi, James B. Bingham, M Josh Hasbani, Steven R. Grill, Trina A. Schroer, and Duane A. Compton

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CD40-CD40 Ligand Interactions in Experimental Allergic Encephalomyelitis and Multiple Sclerosis., Koen Gerritse, Jon D. Laman, Randolph J. Noelle, and Alejandro Aruffo

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Antibody to the Ligand for CD40 (gp39) Inhibits Murine AIDS-associated Splenomegaly, Hypergammaglobulinemia, and Immunodeficiency in Disease-Susceptible C57BL/6 Mice., Kathy A. Green, Karen M. Crassi, Jon D. Laman, Arjan Schoneveld, Rendall R. Strawbridge, Teresa M. Foy, Randolph J. Noelle, and William R. Green

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Attachment of Toxoplasma gondii to Host Cells is Host Cell Cycle Dependent., Jane Grimwood, Jose R. Mineo, and Lloyd H. Kasper

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Cloning of Human Acetyl-CoA Carboxylase-Beta and its Unique Features., Joohun Ha, Jung-Kee Lee, Kyung-Sup Kim, Lee A. Witters, and Ki-Han Kim

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GTPase-deficient G Alpha 16 and G Alpha q Induce PC12 Cell Differentiation and Persistent Activation of cJun NH2-terminal Kinases., Lynn E. Heasley, Brooke Storey, Gary R. Fanger, Laura Butterfield, J Zamarripa, D Blumberg, and R A. Maue

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F(c)gammaRI-Targeted Fusion Proteins result in Efficient Presentation by Human Monocytes of Antigenic and Antagonist T Cell Epitopes, Chunlei Liu, Joel Goldstein, Robert F. Graziano, Jia He, Jeremiah K. O'Shea, Yashwant Deo, and Paul M. Guyre

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Physical Linkage of the Vibrio Cholerae Mannose-Sensitive Hemagglutinin Secretory and Structural Subunit Gene Loci: Identification of the Mshg Coding Sequence., Jane W. Marsh, Daxi Sun, and Ronald K. Taylor

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A Truncated Form of the Pho80 cyclin of Saccharomyces Cerevisiae Induces Expression of a Small Cytosolic Factor which Inhibits Vacuole Inheritance., Teresa Nicolson, Barbara Conradt, and William Wickner

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NuMA Assembles Into an Extensive Filamentous Structure When Expressed in the Cell Cytoplasm, Alejandro Saredi, Louisa Howard, and Duane A. Compton

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Toxin-coregulated Pilus, but Not Mannose-sensitive Hemagglutinin, is Required for Colonization by Vibrio Cholerae O1 El Tor Biotype and O139 Strains., K Helene Thelin and Ronald K. Taylor

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Disruption of the Cbfa2 Gene Causes Necrosis and Hemorrhaging in the Central Nervous System and Blocks Definitive Hematopoiesis., Qing Wang, Terryl Stacy, Michael M Binder, Miguel Marin-Padilla, Arlene H. Sharpe, and Nancy A. Speck

Submissions from 1995

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Strain-Dependent Variation in Carbon Source Regulation of Nucleus-Encoded Mitochondrial Proteins of Saccharomyces Cerevisiae., Timothy A. Brown and Bernard L. Trumpower

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A TEF-1-independent Mechanism for Activation of the Simian Virus 40 (SV40) Late Promoter by Mutant SV40 Large T Antigens., Paul Casaz, Phillip W. Rice, Charles N. Cole, and Ulla Hansen

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Role of 4-1BB Ligand in Costimulation of T Lymphocyte Growth and its Upregulation on M12 B Lymphomas by cAMP, M. A. DeBenedette, N. R. Chu, K. E. Pollok, J. Hurtado, William F. Wade, Byoung S. Kwon, and Tania H. Watts

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Gas1-induced Growth Suppression Requires a Transactivation-independent p53 Function., Giannino Del Sal, Elisabetta M. Ruaro, Rene Utrera, and Charles N. Cole

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Survival of Immunoglobulin G-opsonized Toxoplasma gondii in Nonadherent Human Monocytes., Camilo E. Fadul, Jacqueline Y. Channon, and Lloyd H. Kasper

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The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells., Amitav Hajra, Pu Liu, Qing Wang, and Christine Kelley

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A Toxoplasma gondii-derived Factor(s) Stimulates Immune Downregulation: An in Vitro Model., Sakhina Haque, Azizul Haque, and Lloyd H. Kasper

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Asbestos Induces Nuclear Factor Kappa B (NF-kappa B) DNA-Binding Activity and NF-Kappa B-Dependent Gene Expression in Tracheal Epithelial Cells., Yvonne M. Janssen, Aaron Barchowsky, Melinda Treadwell, Kevin E. Driscoll, and B T. Mossman

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Mutation or Deletion of the Saccharomyces Cerevisiae RAT3/NUP133 Gene causes Temperature-Dependent Nuclear Accumulation of Poly(A)+ RNA and Constitutive Clustering of Nuclear Pore Complexes, Ou Li, Catherine V. Heath, David C. Amberg, Thomas C. Dockendorff, Connie S. Copeland, Michael Snyder, and Charles N. Cole

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Survival of Mouse Pancreatic Islet Allografts in Recipients Treated with Allogeneic Small Lymphocytes and Antibody to CD40 Ligand., David C. Parker, Dale L. Greiner, Nancy E. Phillips, Michael C. Appel, Alan W. Steele, Fiona H. Durie, Randolph J. Noelle, John P. Mordes, and Aldo A. Rossini

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A Novel Translational Regulation Function for the Simian Virus 40 Large-T Antigen Gene., Prithi Rajan, Sathyamagalam Swaminathan, Jiyue Zhu, and Charles N. Cole

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The GTP-Bound Form of the Yeast Ran/TC4 Homologue Blocks Nuclear Protein Import and Appearance of Poly(A)+ RNA in the Cytoplasm., Gabriel Schlenstedt, Claudio Saavedra, Jonathan D. Loeb, Charles N. Cole, and Pamela A. Silver

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Transactivation of the Moloney Murine Leukemia Virus and T-cell Receptor Beta-Chain Enhancers by cbf and ets Requires Intact Binding Sites for Both Proteins., Wanwen Sun, Barbara J. Graves, and Nancy A. Speck

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Polyclonal Mycobacterium Avium Infections in Patients with AIDS: Variations in Antimicrobial Susceptibilities of Different Strains of M. Avium Isolated from the Same Patient., C Fordham von Reyn, Nicholas J. Jacobs, Robert D. Arbeit, Joe N. Maslow, and S Niemczyk

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Patient Reactions to a Program Designed to Facilitate Patient Participation in Treatment Decision for Benign Prostatic Hyperplasia, John E. Wennberg

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The Effect of a Shared Decisionmaking Program on Rates of Surgery for Benign Prostatic Hyperplasia. Pilot Results., John E. Wennberg

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The Nascent-Polypeptide-Associated Complex: Having a "NAC" for Fidelity in Translocation., William Wickner

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Protein-Peptide Interactions Analyzed with the Yeast Two-Hybrid System, Meijia Yang, Zining Wu, and Stanley Fields

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Transcriptional Activity of Core Binding Factor-Alpha (AML1) and Beta Subunits on Murine Leukemia Virus Enhancer Cores., Ari L. Zaiman, Amy F. Lewis, Barbara E. Crute, N. A. Speck, and Jack Lenz

Submissions from 1994

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Circadian Clock Locus Frequency: Protein Encoded by a Single Open Reading Frame Defines Period Length and Temperature Compensation., Benjamin D. Aronson, Keith A. Johnson, and Jay C. Dunlap

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Antibody to the Ligand of CD40, Gp39, Blocks the Occurrence of the Acute and Chronic Forms of Graft-Vs-Host Disease, F H. Durie, A Aruffo, J Ledbetter, and K M. Crassi

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CD40 Ligand Expression is Defective in a Subset of Patients with Common Variable Immunodeficiency., Mary Farrington, Laura S. Grosmaire, Shigeaki Nonoyama, Susanna H. Fischer, Diane Hollenbaugh, Jeffrey A. Ledbetter, and R. J. Noelle

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Adoptive Transfer of Polyclonal and Cloned Cytolytic T Lymphocytes (CTL) Specific for Mouse AIDS-associated Tumors is Effective in Preserving CTL Responses: A Measure of Protection Against LP-BM5 Retrovirus-induced Immunodeficiency., William R. Green, Kathy A. Green, and Karen M. Crassi

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Antiparasitic and Antiproliferative Effects of Indoleamine 2,3-dioxygenase Enzyme Expression in Human Fibroblasts., Sohan L. Gupta, Joseph M. Carlin, Padma Pyati, Wei Dai, Elmer R. Pfefferkorn, and Martin J. Murphy Jr

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Impairment of the Cellular Immune Response in Acute Murine Toxoplasmosis: Regulation of Interleukin 2 Production and Macrophage-mediated Inhibitory Effects., Sakhina Haque, Imtiaz Khan, Azizul Haque, and Lloyd Kasper

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The Random Inactivation of the X Chromosome Carrying the Defective Gene Responsible for X-Linked Hyper IgM Syndrome (X-HIM) in Female Carriers of HIGM1, D Hollenbaugh, L H. Wu, H D. Ochs, and S Nonoyama

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Subunit Dynamics in Escherichia Coli Preprotein Translocase., John C. Joly, Marilyn R. Leonard, and William T. Wickner

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Interleukin-12 Enhances Murine Survival Against Acute Toxoplasmosis., Imtiaz A. Khan, Tadashi Matsuura, and Lloyd H. Kasper

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Binding of Matrix Attachment Regions to Lamin Polymers Involves Single-Stranded Regions and the Minor Groove., M. E. Eva Ludérus, Jan L. den Blaauwen, Oncko J. de Smit, Duane A. Compton, and Roel van Driel

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Contrast Enhancement of Medical Images using Multiscale Edge Representation, Jian Lu, Dennis M. Healy Jr., and John B. Weaver

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BCL-2 Protein Expression is Widespread in the Developing Nervous-System and Retained in the Adult PNS, Diane E. Merry, Deborah J. Veis, William F. Hickey, and Stanley J. Korsmeyer

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The Amino-terminal Functions of the Simian Virus 40 Large T Antigen Are Required to Overcome Wild-type p53-Mediated Growth Arrest of Cells., Robin S. Quartin, Charles N. Cole, James M. Pipas, and Arnold J. Levine

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Polyclonal Infections Due to Mycobacterium Avium Complex in Patients with AIDS Detected by Pulsed-field Gel Electrophoresis of Sequential Clinical Isolates., Alexander M. Slutsky, Robert D. Arbeit, Thomas W. Barber, Josiah Rich, and C Fordham von Reyn

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A Thyroid Hormone-Regulated Gene in Xenopus Laevis Encodes a Type III Iodothyronine 5-Deiodinase., Donald L. St Germain, Robert Schwartzman, Walburga Croteau, Akira Kanamori, Zhou Wang, Donald D. Brown, and Valerie Galton

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Comparison of Cytotoxic Properties of Neonatal and Adult Neutrophils and Monocytes and Enhancement by Cytokines., E . R. Stiehm, R. L. Roberts, B. J. Ank, S. Plaeger-Marshall, N. Salman, L. Shen, and M. W. Fanger

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ROC Curve Regression Analysis: the Use of Ordinal Regression Models for Diagnostic Test Assessment, Anna N.A. Tosteson, Milton C. Weinstein, Jack Wittenberg, and Colin B. Begg

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Regulation of Collagenase Gene Expression by IL-1 Beta Requires Transcriptional and Post-Transcriptional Mechanisms, Matthew P. Vincenti, Charles I. Coon, Oneil Lee, and Constance E. Brinckerhoff

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Cooperative Binding of Ets-1 and Core Binding Factor to DNA., David Wotton, Jacques Ghysdael, Shuwen Wang, Nancy A. Speck, and Michael J. Owen

Submissions from 1993

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The Interplay of Light and the Circadian Clock. Independent Dual Regulation of Clock-Controlled Gene Ccg-2(eas), Guiseppina Arpaia, Jennifer J. Loros, Jay C. Dunlap, Giorgio Morelli, and Guiseppe Macino

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Isolation of Interleukin 2-Induced Immediate-Early Genes., Carol Beadling, Kirk W. Johnson, and Kendall A. Smith

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Increased Collagen-Linked Pentosidine Levels and Advanced Glycosylation End Products in Early Diabetic Nephropathy, Paul J. Beisswenger, Lynn L. Moore, Truls Brinck-Johnsen, and Thomas J. Curphey

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Selective Modulation of Human Natural Killer Cells in vivo after Prolonged Infusion of Low Dose Recombinant Interleukin 2, Michael A. Caligiuri, Christine Murray, Michael J. Robertson, Eunice Wang, Keith Cochran, Christine Cemeron, Peter Schow, Mary E. Ross, Thomas R. Klumpp, Robert J. Soiffer, Kendall A. Smith, and Jerome Ritz

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Porphyrin Accumulation and Export by Isolated Barley (Hordeum vulgare) Plastids (Effect of Diphenyl Ether Herbicides), Judith M. Jacobs and Nicholas J. Jacobs

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Lithium Phthalocyanine: A Probe for Electron Paramagnetic Resonance Oximetry in Viable Biological Systems., K. J. Liu, P. Gast, M. Moussavi, S. W. Norby, N Vahidi, and T Walczak

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Two Factors that Bind to Highly Conserved Sequences in Mammalian Type C Retroviral Enhancers., Nancy R. Manley, Mary M. O'Connell, Wanwen Sun, Nancy A. Speck, and Nancy Hopkins

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Sequence Specificity of the Core-Binding Factor, Irena N. Melnikova, Barbara E. Crute, Shuwen Wang, and Nancy A. Speck

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Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines., Kenneth Peterson, Galynn Zitnik, Clare Huxley, and Christopher Lowrey

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Efficient Transcriptional Activation of Many Simple Modular Promoters by Simian Virus 40 Large T Antigen., Philip W. Rice and Charles N. Cole

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Characterization of a Protein that Binds Multiple Sequences in Mammalian Type C Retrovirus Enhancers., Wanwen Sun, Mary M. O'Connell, and Nancy A. Speck

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Common Elements in Interleukin 4 and Insulin Signaling Pathways in Factor-Dependent Hematopoietic Cells., Ling-Mei Wang, Achsah D. A D Keegan, Weiqun Li, and Gustav E. Lienhard

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Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor., Shuwen Wang, Qing Wang, Barbara E. Crute, Irena N. Melnikova, Susanna R. Keller, and Nancy A. Speck

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Could Distance be a Proxy for Severity-of-Illness? A Comparison of Hospital Costs in Distant and Local Patients., H G. Welch, E B. Larson, and W P. Welch

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Molecular Cloning of Infectious Ecotropic Murine Leukemia Virus AK7 from an emv-14-positive AKXL-5 Mouse and the Resistance of AK7 to Recognition by Cytotoxic T Lymphocytes., Hillary D. White, William R. Green, and Nuria R. Giné

Submissions from 1992

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Mechanisms of Interference with Simian Virus 40 (SV40) DNA Replication by Trans-Dominant Mutants of SV40 Large T Antigen, Christine M. Bentivoglio, Jiyue Zhu, and Charles Cole

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Cytolytic T Lymphocytes Specific for Tumors and Infected Cells from Mice with a Retrovirus-induced Immunodeficiency Syndrome., Jennifer G. Erbe, Kathy A. Green, Karen M. Crassi, Herbert C. Morse, and W R. Green

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Differentiation of Renal Beta-Intercalated Cells to Alpha-Intercalated and Principal Cells in Culture., Geza Fejes-Tóth and Aniko Náray-Fejes-Tóth

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On the Mechanism of Parathyroid Hormone Stimulation of Calcium Uptake by Mouse Distal Convoluted Tubule Cells, F A. Gesek and A. Friedman

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Mechanism of Calcium Transport Stimulated by Chlorothiazide in Mouse Distal Convoluted Tubule Cells., Frank A. Gesek and Peter A. Friedman

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Modulation of Cisplatin Sensitivity and Growth Rate of an Ovarian Carcinoma Cell Line by Bombesin and Tumor Necrosis Factor-Alpha., Seiji Isonishi, Antti P. Jekunen, Doreen K. Hom, Alan Eastman, Peter S. Edelstein, Franz B. Thiebaut, Randolph D. Christen, and Stephen B. Howell

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Differential Regulation of Collagenase Gene Expression by Retinoic Acid Receptors--Alpha, Beta And Gamma, Luying Pan, Stephen H. Chamberlain, David T. Auble, and Constance E. Brinckerhoff

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A Phorbol Ester Response Element within the Human T-Cell Receptor Beta-Chain Enhancer., Haydn M. Prosser, David Wotton, Anne Gegonne, Jacques Ghysdael, Shuwen Wang, Nancy A. Speck, and Michael J. Owen

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Indistinguishable Nuclear Factor Binding to Functional Core Sites of the T-Cell Receptor Delta and Murine Leukemia Virus Enhancers., Juan M. Redondo, Jeffrey L. Pfohl, Cristina Hernandez-Munain, Shuwen Wang, Nancy A. Speck, and Michael S. Krangel

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Adenosine Regulates a Chloride Channel via Protein Kinase C and a G Protein in a Rabbit Cortical Collecting Duct Cell Line., Erik M. Schwiebert, Katherine H. Karlson, Peter A. Friedman, Paul Dietl, William S. Spielman, and Bruce Stanton

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Purification of Core-Binding Factor, a Protein that Binds the Conserved Core Site in Murine Leukemia Virus Enhancers., Shuwen W. Wang and Nancy A. Speck

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Transformation of a Continuous Rat Embryo Fibroblast Cell Line Requires Three Separate Domains of Simian Virus 40 Large T Antigen., Jiyue Zhu, Philip W. Rice, Lisa Gorsch, Marina Abate, and Charles N. Cole

Submissions from 1991

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Reaction of Chromium(VI) with Glutathione or with Hydrogen Peroxide: Identification of Reactive Intermediates and their Role in Chromium(VI)-Induced DNA Damage, J Aiyar, H Berkovits, R Floyd, and K Wetterhahn

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Association of Circulating Receptor Fc Gamma RIII-Positive Monocytes in AIDS Patients with Elevated Levels of Transforming Growth Factor-Beta, J B. Allen, H L. Wong, P M. Guyre, and G L. Simon

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Fc Receptors for IgG (Fc gamma Rs) on Human Monocytes and Macrophages Are Not Infectivity Receptors for Human Immunodeficiency Virus Type 1 (HIV-1): Studies Using Bispecific Antibodies to Target HIV-1 to Various Myeloid Cell Surface Molecules, including the Fc Gamma R., R I. Connor, N B. Dinces, A L. Howell, J L. Romet-Lemonne, J L. Pasquali, and M W. Fanger

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Evidence for Attenuation of Myo-Inositol Uptake, Phosphoinositide Turnover and Inositol Phosphate Production in Aortic Vasculature of Rats During Pregnancy, Kirk P. Conrad, Susan A. Barrera, Peter A. Friedman, and Vicki M. Schmidt

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A Polymerase Chain Reaction-Based Method to Detect Cisplatin Adducts in Specific Genes, M M. Jennerwein and A Eastman