This collection contains works by faculty from the Geisel School of Medicine.

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Submissions from 2001

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Clumping Factor A Mediates Binding of Staphylococcus aureus to Human Platelets, Ian R. Siboo, Ambrose L. Cheung, Arnold S. Bayer, and Paul M. Sullam

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Firefly Flashing is Controlled by Gating Oxygen to Light-Emitting Cells, G. S. Timmins, F. J. Robb, C. M. Wilmot, S. K. Jackson, and H. M. Swartz

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Distinct Retrieval and Retention Mechanisms are Required for the Quality Control of Endoplasmic Reticulum Protein Folding, Shilpa Vashist, Woong Kim, William J. Belden, Eric D. Spear, Charles Barlowe, and Davis T.W. Ng

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Anti-Class II Monoclonal Antibody-Targeted Vibrio cholerae TcpA Pilin: Modulation of Serologic Response, Epitope Specificity, and Isotype, Jia-Yan Wu, Ronald K. Taylor, and William F. Wade

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Evaluation of Cholera Vaccines Formulated with Toxin-Coregulated Pilin Peptide Plus Polymer Adjuvant in Mice, Jia-Yan Wu, William F. Wade, and Ronald K. Taylor

Submissions from 2000

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Asymmetric Requirements for a Rab Gtpase and Snare Proteins in Fusion of Copii Vesicles with Acceptor Membranes, Xiaochun Cao and Charles Barlowe

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Differential Infectivity and Division of Toxoplasma gondii in Human Peripheral Blood Leukocytes, Jacqueline Y. Channon, Rosanne M. Seguin, and Lloyd H. Kasper

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Microbial Biofilms: From Ecology to Molecular Genetics, Mary Ellen Davey and George A. O'toole

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Attachment of Toxoplasma gondii to a Specific Membrane Fraction of CHO Cells, Chaitali Dutta, Jane Grimwood, and Lloyd H. Kasper

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Applications of magnetic resonance in model systems: Cancer therapeutics, Jeffrey L. Evelhoch, Robert J. Gillies, Gregory S. Karczmar, Jason A. Koutcher, Ross J. Maxwell, Orhan Nalcioglu, Natarajan Raghunand, Sabrina M. Ronen, Brian D. Ross, and Harold M. Swartz

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Associations among Hospital Capacity, Utilization, and Mortality of US Medicare Beneficiaries, Controlling for Sociodemographic Factors., E. S. Fisher, J. E. Wennberg, T. A. Stukel, J. S. Skinner, and S. M. Sharp

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Lineage-Restricted Function of Nuclear Factor KappaB-Inducing Kinase (NIK) in Transducing Signals Via CD40., Norman Garceau, Yoko Kosaka, Sally Masters, John Hambor, Reiko Shinkura, Tasuko Honjo, and Randolph J. Noelle

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Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2, Tamara L. Goetz, Ting-Lei Gu, Nancy A. Speck, and Barbara J. Graves

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Staphylococcus aureus RN6390 Replicates and Induces Apoptosis in a Pulmonary Epithelial Cell Line, Barbara C. Kahl, Mark Goulian, Willem van Wamel, Mathias Herrmann, Sanford M. Simon, Gilla Kaplan, Georg Peters, and Ambrose L. Cheung

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Effects of Estradiol and Progesterone on Susceptibility and Early Immune Responses to Chlamydia trachomatis Infection in the Female Reproductive Tract, Charu Kaushic, Fan Zhou, Andrew D. Murdin, and Charles R. Wira

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Naturally Occurring TAP-Dependent Specific T-Cell Tolerance for a Variant of an Immunodominant Retroviral Cytotoxic T-Lymphocyte Epitope, Victor Kim, Jonathan W. Yewdell, and William R. Green

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Differential Activation of the tcpPH Promoter by AphB Determines Biotype Specificity of Virulence Gene Expression in Vibrio cholerae, Gabriela Kovacikova and Karen Skorupski

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Phosphorylation of the Neurospora Clock Protein FREQUENCY Determines its Degradation Rate and Strongly Influences the Period Length of the Circadian Clock, Yi Liu, Jennifer Loros, and Jay C. Dunlap

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Chemopreventive Effect of Oltipraz on AFB1-Induced Hepatocarcinogenesis in Tree Shrew Model, Yuan Li, Jian Jia Su, Liu L. Qin, Chun Yang, Dan Luo, Ke C. Ban, T. W. Kensler, and B. D. Roebuck

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Anti-Gag Cytolytic T Lymphocytes Specific for an Alternative Translational Reading Frame-Derived Epitope and Resistance Versus Susceptibility to Retrovirus-Induced Murine AIDS in F1 Mice, Shawn-Marie Mayrand, Patricia A. Healy, Bruce E. Torbett, and William R. Green

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Lack of CD4+ T Cells Does Not Affect Induction of CD8+ T-Cell Immunity against Encephalitozoon cuniculi Infection, Magali Moretto, Lori Casciotti, Brigit Durell, and Imtiaz A. Khan

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Vibrio cholerae H-NS Silences Virulence Gene Expression at Multiple Steps in the ToxR Regulatory Cascade, Melinda B. Nye, James D. Pfau, Karen Skorupski, and Ronald K. Taylor

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The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa, George A. O'Toole, Karine A. Gibbs, Paul W. Hager, Paul V. Phibbs, and Roberto Kolter

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The Docking Stage of Yeast Vacuole Fusion Requires the Transfer of Proteins from a Cis-Snare Complex to a Rab/Ypt Protein, Albert Price, Darren Seals, William Wickner, and Christian Ungermann

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Proteins Needed for Vesicle Budding from the Golgi Complex are Also Required for the Docking Step of Homotypic Vacuole Fusion, Albert Price, William Wickner, and Christian Ungermann

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Inhibition of Antiviral CTL Responses by Virus-Infected Cells: Line Item Veto (Cells) Revisited, Robert F. Rich and William R. Green

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A Ypt/Rab Effector Complex Containing the Sec1 Homolog Vps33p is Required for Homotypic Vacuole Fusion, Darren F. Seals, Gary Eitzen, Nathan Margolis, William T. Wickner, and Albert Price

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Direct Determination of the Kinetics of Oxygen Diffusion to the Photocytes of a Bioluminescent Elaterid Larva, Measurement of Gas- and Aqueous-Phase Diffusional Barriers and Modelling of Oxygen Supply, G. S. Timmins, E. J. Bechara, and H. M. Swartz

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A New Role for a SNARE Protein as a Regulator of the Ypt7/Rab-Dependent Stage of Docking, Christian Ungermann, Albert Price, and William Wickner

Submissions from 1999

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Immune Responses Induced by Gene Gun or Intramuscular Injection of DNA Vaccines That Express Immunogenic Regions of the Serine Repeat Antigen from Plasmodium falciparum, Alexia A. Belperron, David Feltquate, Barbara A. Fox, Toshihiro Horii, and David J. Bzik

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Attachment Ligands of Viable Toxoplasma gondii Induce Soluble Immunosuppressive Factors in Human Monocytes, Jacqueline Y. Channon, Edward I. Suh, Rosanne M. Seguin, and Lloyd H. Kasper

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Detection of Toxoplasma gondii soluble antigen, SAG-1 (p30), antibody and immune complex in the cerebrospinal fluid of HIV positive or negative individuals, Flávia A. Chaves-Borges, Maria A. Souza, Deise A.O. Silva, Lloyd H. Kasper, and José R. Mineo

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Dichotomy between Naïve and Memory CD4+ T Cell Responses to Fas Engagement, J. Desbarats, T. Wade, W. F. Wade, and M. K. Newell

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Pregnant Rat Uterus Expresses High Levels of the Type 3 Iodothyronine Deiodinase, Valerie Anne Galton, Elena Martinez, Arturo Hernandez, Emily A. St. Germain, Joanne M. Bates, and Donald L. St. Germain

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Mechanisms of Immunotherapeutic Intervention by Anti-CD40L (CD154) Antibody in an Animal Model of Multiple Sclerosis, Laurence M. Howard, Amy J. Miga, Carol L. Vanderlugt, Mauro C. Dal Canto, John D. Laman, Randolph J. Noelle, and Stephen D. Miller

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Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice, Mark S. Hu, Joseph D. Schwartzman, Grant R. Yeaman, Jane Collins, Rosanne Seguin, Imtiaz A. Khan, and Lloyd H. Kasper

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Immune CD8+ T Cells Prevent Reactivation of Toxoplasma gondii Infection in the Immunocompromised Host, Imtiaz A. Khan, William R. Green, Lloyd H. Kasper, Kathy A. Green, and Joseph D. Schwartzman

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Role of Gamma Interferon in Cellular Immune Response against Murine Encephalitozoon cuniculi Infection, Imtiaz A. Khan and Magali Moretto

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A Vibrio Cholerae LysR Homolog, AphB, Cooperates with AphA at the tcpPH Promoter To Activate Expression of the ToxR Virulence Cascade, Gabriela Kovacikova and Karen Skorupski

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Core-Binding Factor Influences the Disease Specificity of Moloney Murine Leukemia Virus, Amy F. Lewis, Terryl Stacy, William R. Green, Lekidelu Taddesse-Heath, Janet W. Hartley, and Nancy A. Speck

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Genetic and Transcriptional Analyses of the Vibrio cholerae Mannose-Sensitive Hemagglutinin Type 4 Pilus Gene Locus, Jane W. Marsh and Ronald K. Taylor

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The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle, Vicki Mountain, Calvin Simerly, Louisa Howard, Asako Ando, Gerald Schatten, and Duane A. Compton

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A PDZ-Interacting Domain in CFTR is an Apical Membrane Polarization Signal, Bryan D. Moyer, Jerod Denton, Katherine H. Karlson, Donna Reynolds, Shusheng Wang, John E. Mickle, Michael Milewski, Garry R. Cutting, William B. Guggino, Min Li, and Bruce A. Stanton

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Differential Transcription of the tcpPH Operon Confers Biotype-Specific Control of the Vibrio cholerae ToxR Virulence Regulon, Yvette M. Murley, Patricia A. Carroll, Karen Skorupski, Ronald K. Taylor, and Stephen B. Calderwood

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Cbfa2 is Required for the Formation of Intra-Aortic Hematopoietic Clusters, Trista North, Ting-Lei Gu, Stacy Terryl, Qing Wang, Louisa Howard, Michael Binder, Miguel Marín-Padilla, and Nancy A. Speck

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Interruption of Multiple Cellular Processes in HT-29 Epithelial Cells by Pseudomonas aeruginosa Exoenzyme S, Joan C. Olson, Jennifer E. Fraylick, Eileen M. McGuffie, Katherine M. Dolan, Timothy L. Yahr, Dara W. Frank, and Timothy S. Vincent

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Dynactin is Required for Microtubule Anchoring at Centrosomes, N J. Quintyne, S. R. Gill, D M. Eckley, C L. Crego, D A. Compton, and T A. Schroer

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Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4+ and CD8+ Antiviral T Cells by Viral Antigen-Positive Veto Cells, Robert F. Rich and William R. Green

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A Ligand Binding Domain Mutation in the Mouse Glucocorticoid Receptor Functionally Links Chromatin Remodeling and Transcription Initiation, Lynn A. Sheldon, Catharine L. Smith, Jack E. Bodwell, Allan U. Munck, and Gordon L. Hager

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Interpreting Patterns of Gene Expression with Self-Organizing Maps: Methods and Application to Hematopoietic Differentiation, Pablo Tamayo, Donna Slonim, Jill Mesirov, Qing Zhu, Sutisak Kitareewan, and Ethan Dmitrovsky

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Measurement of Oxygen Partial Pressure, its Control During Hypoxia and Hyperoxia, and its Effect upon Light Emission in a Bioluminescent Elaterid Larva, G. S. Timmins, C. A. A. Penatti, E. J. H. Bechara, and H. M. Swartz

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Three v-SNAREs and Two t-SNAREs, Present in a Pentameric cis-SNARE Complex on Isolated Vacuoles, Are Essential for Homotypic Fusion, Christian Ungermann, Gabriele F. von Mollard, Ole N. Jensen, Nathan Margolis, Tom H. Stevens, and William Wickner

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Vacuole Acidification is Required for Trans-SNARE Pairing, LMA1 Release, and Homotypic Fusion, Christian Ungermann, William Wickner, and Zuoyu Xu

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Sec34p, a Protein Required for Vesicle Tethering to the Yeast Golgi Apparatus, is in a Complex with Sec35p, Susan M. VanRheenen, Xiaochun Cao, Stephanie K. Sapperstein, Elbert C. Chiang, Vladimir V. Lupashin, Charles Barlowe, and M. Gerard Waters

Submissions from 1998

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The Leukemic Protein Core Binding Factor Beta (CBFbeta)-Smooth-Muscle Myosin Heavy Chain Sequesters CBFalpha2 into Cytoskeletal Filaments and Aggregates, Neeraj Adya, Terryl Stacy, Nancy A. Speck, and Pu Paul Liu

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CD4(+) T Cells Tolerized Ex Vivo to Host Alloantigen by Anti-CD40 Ligand (CD40L:CD154) Antibody Lose their Graft-Versus-Host Disease Lethality Capacity but Retain Nominal Antigen Responses., Bruce R. Blazar, Patricia A. Taylor, Randolph J. Noelle, and Daniel A. Vallera

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Drosophila Fascin Mutants are Rescued by Overexpression of the Villin-like Protein, Quail, Kelly Cant, Brenda A. Knowles, Shalina Mahajan-Miklos, Matthew Heintzelman, and Lynn Cooley

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Heterologous Complementation Reveals that Mutant Alleles of QSR1 Render 60S Ribosomal Subunits Unstable and Translationally Inactive, Frederick A. Dick and Bernard L. Trumpower

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The SecA Subunit of Escherichia coli Preprotein Translocase Is Exposed to the Periplasm, Jerry Eichler and William Wickner

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Subcellular Localization of Mineralocorticoid Receptors in Living Cells: Effects of Receptor Agonists and Antagonists, Géza Fejes-Tóth, David Pearce, and Anikó Náray-Fejes-Tóth

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Identification and Characterization of SpcU, a Chaperone Required for Efficient Secretion of the ExoU Cytotoxin, Viviane Finck-Barbançon, Timothy L. Yahr, and Dara W. Frank

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How do HMOs Achieve Savings? The Effectiveness of One Organization's Strategies., Ann B. Flood, Allen M. Fremont, K Jin, and David M. Bott

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The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles, Mercedes Gonzalez, Fabienne Mackay, Jeffrey L. Browning, Marie H. Kosco-Vilbois, and Randolph J. Noelle

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Molecular Basis for Effects of Carcinogenic Heavy Metals on Inducible Gene Expression, Joshua W. Hamilton, Ronald C. Kaltreider, Olga V. Bajenova, Michael A. Ihnat, Jennifer McCaffrey, Bruce W. Turpie, Erin E. Rowell, Jannet Oh, Michael J. Nemeth, Carrie A. Pesce, and Jean P. Lariviere

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Interprofessional Working and Continuing Medical Education., Linda Headrick, Peter Wilcock, and Paul Batalden

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Design of an Epidemiologic Study of Drinking Water Arsenic Exposure and Skin and Bladder Cancer Risk in a U.S. Population, Margaret R. Karagas, Tor D. Tosteson, Joel Blum, J Steven Morris, John A. Baron, and Bjoern Klaue

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Hormone Replacement Therapy and Risk of Hip Fracture: Population Based Case-Control Study, Karl Michaëlsson, John A. Baron, Bahman Y. Farahmand, Olof Johnell, Cecilia Magnusson, Per-Gunnar Persson, Ingemar Persson, and Sverker Ljunghall

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Antigen-Specific CD8+ T Cells Protect against Lethal Toxoplasmosis in Mice Infected with Neospora caninum, Lloyd H. Kasper and Imtiaz A. Khan

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Chlamydia trachomatis Infection in the Female Reproductive Tract of the Rat: Influence of Progesterone on Infectivity and Immune Response, Charu Kaushic, Andrew D. Murdin, Brian J. Underdown, and Charles R. Wira

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The “Spot 14” Gene Resides on the Telomeric End of the 11q13 Amplicon and is Expressed in Lipogenic Breast Cancers: Implications for Control of Tumor Metabolism, Joel T. Moncur, Jonathan P. Park, Vincent A. Memoli, T. K. Mohandas, and William B. Kinlaw

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A Longitudinal Study of Hospitalization Rates for Patients with Chronic Disease: Results from the Medical Outcomes Study., Eugene C. Nelson, Colleen A. McHorney, Willard G. Manning, and W H. Rogers

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Conserved Elements Containing NF-E2 and Tandem GATA Binding Sites are Required for Erythroid-Specific Chromatin Structure Reorganization within the Human Beta-Globin Locus Control Region, Oded Pomerantz, Andrew J. Goodwin, Terrence Joyce, and Christopher H. Lowrey

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Transport of Axl2p Depends on Erv14p, an ER–Vesicle Protein Related to the Drosophila cornichon Gene Product, Jacqueline Powers and Charles Barlowe

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Overexpression of Glyoxalase-I in Bovine Endothelial Cells Inhibits Intracellular Advanced Glycation Endproduct Formation and prevents hyperglycemia-induced increases in macromolecular endocytosis., Moritsugu Shinohara, P J. Thornalley, Ida Giardino, Paul Beisswenger, Suzanne R. Thorpe, Joelle Onorato, and Michael Brownlee

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Expression of Toxoplasma gondii-Specific Heat Shock Protein 70 during In Vivo Conversion of Bradyzoites to Tachyzoites, Neide M. Silva, Ricardo T. Gazzinelli, Deise A. O. Silva, Eloisa A. V. Ferro, Lloyd H. Kasper, and Jose R. Mineo

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Investigation of the Roles of Toxin-Coregulated Pili and Mannose-Sensitive Hemagglutinin Pili in the Pathogenesis of Vibrio cholerae O139 Infection, Carol O. Tacket, Ronald K. Taylor, Genevieve Losonsky, and Yu Lim

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A Vacuolar v–t-SNARE Complex, the Predominant Form In Vivo and on Isolated Vacuoles, Is Disassembled and Activated for Docking and Fusion, Christian Ungermann, Benjamin J. Nichols, Hugh R. B. Pelham, and William Wickner

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Sec35p, a Novel Peripheral Membrane Protein, Is Required for ER to Golgi Vesicle Docking, Susan M. VanRheenen, Xiaochun Cao, Vladimir V. Lupashin, Charles Barlowe, and M. Gerard Waters

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Adenoma Characteristics at First Colonoscopy as Predictors of Adenoma Recurrence and Characteristics at Follow-Up, Rosalind U. van Stolk, Gerald J. Beck, John A. Baron, Robert Haile, and Robert Summers

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ExoY, an Adenylate Cyclase Secreted by the Pseudomonas Aeruginosa Type III System, Timothy L. Yahr, Amy J. Vallis, Michael Hancock, Joseph T. Barbieri, and Dara W. Frank

Submissions from 1997

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Increased focal Adhesion Kinase- and Urokinase-Type Plasminogen Activator Receptor-Associated Cell Signaling in Endothelial Cells Exposed to Asbestos, A Barchowsky, B M. Lannon, L C. Elmore, and M D. Treadwell

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Coupled ER to Golgi Transport Reconstituted with Purified Cytosolic Proteins, Charles Barlowe

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SCH 48973: a Potent, Broad-Spectrum, Antienterovirus Compound., Peter J. Buontempo, Stuart Cox, Jacquelyn Wright-Minogue, Jason L. DeMartino, Angela M. Skelton, Eric Ferrari, Randi Albin, Edward J. Rozhon, V. Girijavallabhan, John F. Modlin, and John F. O'Connell

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Analysis of Enhancer Function of the HS-40 Core Sequence of the Human Alpha-Globin Cluster, Hsiaoli Chen, Christopher H. Lowrey, and George Stamatoyannopoulos

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Identification of a Novel Antiapoptotic Functional Domain in Simian Virus 40 Large T Antigen., Suzanne D. Conzen, Christine A. Snay, and Charles N. Cole

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C-terminal Truncations of the Yeast Nucleoporin Nup145p Produce a Rapid Temperature-conditional mRNA Export Defect and Alterations to Nuclear Structure., Thomas C. Dockendorff, Catherine V. Heath, Alan L. Goldstein, Christine A. Snay, and C N. Cole

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Both an N-Terminal 65-Kda Domain and a C-Terminal 30-Kda Domain of Seca Cycle into the Membrane at Secyeg During Translocation, Jerry Eichler and William Wickner

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SQT1, which Encodes an Essential WD Domain Protein of Saccharomyces Cerevisiae, Suppresses Dominant-negative Mutations of the Ribosomal Protein Gene QSR1., Dominic P. Eisinger, Frederick A. Dick, Elke Denke, and Bernard L. Trumpower

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Qsr1p, a 60S Ribosomal Subunit Protein, is Required for Joining of 40S and 60S Subunits., Dominic P. Eisinger, Frederick A. Dick, and Bernard L. Trumpower

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Long-inverse PCR to generate regional peptide libraries by codon mutagenesis, Dominic P. Eisinger and Bernard L. Trumpower

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ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers, Batu Erman, Marta Cortes, Barbara S. Nikolajczyk, Nancy A. Speck, and Ranjan Sen

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Analysis of Mutant Platelet-derived Growth Factor Receptors Expressed in PC12 Cells Identifies Signals Governing Sodium Channel Induction during Neuronal Differentiation., Gary R. Fanger, Richard R. Vaillancourt, Lynn E. Heasley, Jean-Pierre P. Montmayeur, Gary L. Johnson, and Robert A. Maue

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Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes, Tirso Gaglio, Mary A. Dionne, and Duane A. Duane A. Compton

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The Type 2 Iodothyronine Deiodinase is Expressed Primarily in Glial Cells in the Neonatal Rat Brain, Ana Guadaño-Ferraz, Maria Jesus Obregón, Donald L. St. Germain, and Juan Bernal

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Human Immunodeficiency Virus Type 1 Infection of Cells and Tissues from the Upper and Lower Human Female Reproductive Tract, Alexandra L. Howell, Robert D. Edkins, Sherry E. Rier, Grant R. Yeaman, Judy E. Stern, Michael W. Fanger, and Charles R. Wira

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A Dichotomous Role for Nitric Oxide During Acute Toxoplasma gondii Infection in Mice, Imtiaz A. Khan, Joseph D. Schwartzman, Tadashi Matsuura, and Lloyd H. Kasper

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The Role of Proximal and Distal Sequence Variations in the Presentation of an Immunodominant CTL Epitope Encoded by the Ecotropic AK7 MuLV, Victor Kim and William R. Green

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Assembly and Regulation of the CD40 Receptor Complex in Human B Cells, Michelle R. Kuhné, Michael Robbins, John E. Hambor, Matthew F. Mackey, Yoko Kosaka, Toshihide Nishimura, Jason P. Gigley, Randolph J. Noelle, and David M. Calderhead

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The Glucose Transporter GLUT4 and the Aminopeptidase vp165 Colocalise in Tubulo-Vesicular Elements in Adipocytes and Cardiomyocytes, Sally Martin, Jacqueline E. Rice, Gwyn W. Gould, and Susanna R. Keller

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Docking of Yeast Vacuoles is Catalyzed by the Ras-like GTPase Ypt7p after Symmetric Priming by Sec18p (NSF), Andreas Mayer and William Wickner