This collection contains works by faculty from the Geisel School of Medicine.

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Submissions from 2007

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A Developmental Cycle Masks Output from the Circadian Oscillator Under Conditions of Choline Deficiency in Neurospora, Mi Shi, Luis F. Larrondo, Jennifer J. Loros, and Jay C. Dunlap

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Endothelial Stomatal and Fenestral Diaphragms in Normal Vessels and Angiogenesis, R. V. Stan

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A Novel RUNX2 Missense Mutation Predicted to Disrupt DNA Binding Causes Cleidocranial Dysplasia in a Large Chinese Family with Hyperplastic Nails, Shaohua Tang, Qiyu Xu, Xueqin Xu, Jicheng Du, Xuemei Yang, Yusheng Jiang, Xiaoqin Wang, Nancy Speck, and Taosheng Huang

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Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+, Wolfram Tempel, Wael M. Rabeh, Katrina L. Bogan, Peter Belenky, Marzena Wojcik, Heather F. Seidle, Lyudmila Nedyalkova, Tianle Yang, Anthony A. Sauve, Hee-Won Park, and Charles Brenner

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Factors Associated with Atypical Moles in New Hampshire, USA, L Titus-Ernstoff, J Ding, A. E. Perry, S. K. Spencer, B. F. Cole, and M. S. Ernstoff

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Membrane Association and Multimerization of TcpT, the Cognate ATPase Ortholog of the Vibrio cholerae Toxin-Coregulated-Pilus Biogenesis Apparatus, Shital A. Tripathi and Ronald K. Taylor

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Role of Actin Cytoskeletal Dynamics in Activation of the Cyclic AMP Pathway and HWP1 Gene Expression in Candida Albicans, Michael J. Wolyniak and Paula Sundstrom

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The Flagellum of Pseudomonas aeruginosa Is Required for Resistance to Clearance by Surfactant Protein A, Shiping Zhang, Francis X. McCormack, Roger C. Levesque, George A. O'Toole, and Gee W. Lau

Submissions from 2006

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Cdx4 Dysregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model, Dimple Bansal, Claudia Scholl, Stefan Frohling, Elizabeth McDowell, Benjamin H. Lee, Konstanze Döhner, and Patricia Ernst

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Transposon Disruption of the Complex I NADH Oxidoreductase Gene (snoD) in Staphylococcus aureus Is Associated with Reduced Susceptibility to the Microbicidal Activity of Thrombin-Induced Platelet Microbicidal Protein 1, Arnold S. Bayer, Peter McNamara, Michael R. Yeaman, Natalie Lucindo, Tiffanny Jones, and Ambrose L. Cheung

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Erv26p Directs Pro-Alkaline Phosphatase into Endoplasmic Reticulum–derived Coat Protein Complex II Transport Vesicles, Catherine A. Bue, Christine M. Bentivoglio, and Charles Barlowe

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Lack of IL-15 Results in the Suboptimal Priming of CD4+ T Cell Response against an Intracellular Parasite, Crescent L. Combe, Magali M. Moretto, Joseph D. Schwartzman, Jason P. Gigley, David J. Bzik, and Imtiaz A. Khan

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Keeping Their Options Open: Acute versus Persistent Infections, S. Furukawa, S. L. Kuchma, and G. A. O'Toole

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CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68, Shinichiro Fuse, Joshua J. Obar, Sarah Bellfy, Erica K. Leung, Weijun Zhang, and Edward J. Usherwood

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Type 3 Deiodinase is Critical for the Maturation and Function of the Thyroid Axis, Arturo Hernandez, M. Elena Martinez, Steven Flering, Valerie Anne Galton, and Donald St. German

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Talking to Themselves: Autoregulation and Quorum Sensing in Fungi, Deborah A. Hogan

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Staphylococcus aureus Escapes More Efficiently from the Phagosome of a Cystic Fibrosis Bronchial Epithelial Cell Line than from Its Normal Counterpart, Todd M. Jarry and Ambrose L. Cheung

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Vulnerability of Pathogenic Biofilms to Micavibrio Aeruginosavorus, Daniel Kadouri, Nel C. Venzon, and George A. O'Toole

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Do CD1-Restricted T Cells Contribute to Antibody-Mediated Immunity against Mycobacterium tuberculosis?, Mark L. Lang and Aharona Glatman-Freedman

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A PDZ-binding Motif as a Critical Determinant of Rho Guanine Exchange Factor Function and Cell Phenotype, Miaoliang Liu and Arie Horowitz

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Structural and Function Analyses of the Global Regulatory Protein SarA from Staphylococcus Aureus, Yingfang Liu, Adhar C. Manna, Cheol-Ho Pan, and Irina A. Kriksunov

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The Role of CD4 T Cells in the Pathogenesis of Murine AIDS, Wen Li and William R. Green

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Circadian Rhythmicity by Autocatalysis, Arun Mehra, Christian I. Hong, Mi Shi, Jennifer J. Loros, Jay C. Dunlap, and Peter Ruoff

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Conservation of the Pho regulon in Pseudomonas Fluorescens Pf0-1, Russell D. Monds, Peter D. Newell, Julia A. Schwartzman, and George A. O'Toole

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GPNN: Power Studies and Applications of a Neural Network Method for Detecting Gene-Gene Interactions in Studies of Human Disease, Alison A. Motsinger, Stephen L. Lee, George Mellick, and Marylyn D. Ritchie

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Binding of Internalized Receptors to the PDZ Domain of GIPC/Synectin Recruits Myosin VI to Endocytic Vesicles, Samia N. Naccache, Tama Hasson, and Arie Horowitz

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Gammaherpesvirus Persistence Alters Key CD8 T-Cell Memory Characteristics and Enhances Antiviral Protection, Joshua J. Obar, Shinichiro Fuse, Erica K. Leung, Sarah C. Bellfy, and Edward J. Usherwood

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Innate Antiviral Response Targets HIV-1 Release by the Induction of Ubiquitin-Like Protein ISG15, Atsushi Okumura, Gengshi Lu, Ian Pitha-Rowe, and Paula M. Pitha

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Nucleolin Is Required for RNA Polymerase I Transcription In Vivo, Brendan Rickards, S. Flint, Michael D. Cole, and Gary LeRoy

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Transcutaneous Immunization with Toxin-Coregulated Pilin A Induces Protective Immunity against Vibrio cholerae O1 El Tor Challenge in Mice, Julianne E. Rollenhagen, Anuj Kalsy, Francisca Cerda, and Manohar John

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Saccharomyces Cerevisiae-Based Molecular Tool Kit for Manipulation of Genes from Gram-Negative Bacteria, Robert M. Q. Shanks, Nicky C. Caiazza, Shannon M. Hinsa, Christine M. Toutain, and George A. O'Toole

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Dissecting Trait Heterogeneity: a Comparison of Three Clustering Methods Applied to Genotypic Data, Tricia A. Thornton-Wells, Jason H. Moore, and Jonathan L. Haines

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Cardiac-Specific Elevations in Thyroid Hormone Enhance Contractility and Prevent Pressure Overload-Induced Cardiac Dysfunction, Maria G. Trivieri, Gavin Y. Oudit, Rajan Sah, Benoit-Giles Kerfant, Hui Sun, Anthony O. Gramolini, Yan Pan, Alan D. Wickenden, and Walburga Croteau

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Prophylaxis and Therapy of Inhalational Anthrax by a Novel Monoclonal Antibody to Protective Antigen That Mimics Vaccine-Induced Immunity, Laura Vitale, Diann Blanset, Israel Lowy, Thomas O'Neill, Joel Goldstein, Stephen F. Little, Gerard P. Andrews, Gary Dorough, Ronald K. Taylor, and Tibor Keler

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The Allantois and Chorion, when Isolated before Circulation or Chorio-Allantoic Fusion, have Hematopoietic Potential, Brandon M. Zeigler, Daisuke Sugiyama, Michael Chen, Yalin Guo, K. M. Downs, and N. A. Speck

Submissions from 2005

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A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions, Soumya Awasthi, Anima Sharma, Kasuen Wong, Junyu Zhang, Elizabeth F. Matlock, Lowery Rogers, Pamela Motloch, Shigeki Takemoto, Hirokuni Taguchi, and Michael D. Cole

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A Rab Requirement is Not Bypassed in SLY1-20 Suppression, Nicole Ballew, Yiting Liu, and Charles Barlowe

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Endothelial-Specific Expression of Caveolin-1 Impairs Microvascular Permeability and Angiogenesis, Philip M. Bauer, Jun Yu, Yan Chen, Reed Hickey, Pascal N. Bernatchez, Robin Looft-Wilson, Yan Huang, Frank Giordano, Radu V. Stan, and William C. Sessa

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Identification of a TcpC-TcpQ Outer Membrane Complex Involved in the Biogenesis of the Toxin-Coregulated Pilus of Vibrio cholerae, Niranjan Bose and Ronald K. Taylor

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Rhamnolipids Modulate Swarming Motility Patterns of Pseudomonas aeruginosa, Nicky c. Caiazza, Robert M. Q. Shanks, and G. A. O'Toole

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Role of the Distal sarA Promoters in SarA Expression in Staphylococcus aureus, Ambrose L. Cheung and Adhar C. Manna

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Effects of Estradiol on Lipopolysaccharide and Pam3Cys Stimulation of CCL20/Macrophage Inflammatory Protein 3 Alpha and Tumor Necrosis Factor Alpha Production by Uterine Epithelial Cells in Culture, Mardi A. Crane-Godreau and Charles R. Wira

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CCL20/Macrophage Inflammatory Protein 3α and Tumor Necrosis Factor Alpha Production by Primary Uterine Epithelial Cells in Response to Treatment with Lipopolysaccharide or Pam3Cys, M. A. Crane-Godreau and C. R. Wira

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Growth Factor–Induced Shedding of Syndecan-1 Confers Glypican-1 Dependence on Mitogenic Responses of Cancer Cells, Kan Ding, Martha Lopez-Burks, José A. Sánchez-Duran, Murray Korc, and Arthur D. Lander

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Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size, Rachel M. Easton, Han Cho, Kristin Roovers, and Diana W. Shineman

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A Gene Expression Fingerprint of C. Elegans Embryonic Motor Neurons, Rebecca M. Fox, Stephen E. Von Stetina, Susan J. Barlow, Christian Shaffer, Kellen L. Olszewski, and Jason H. Moore

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Genetic and Molecular Analysis of Phytochromes from the Filamentous Fungus Neurospora Crassa, Allan C. Froehlich, Bosl Noh, Richard D. Vierstra, Jennifer Loros, and Jay C. Dunlap

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A Critical Role for the Programmed Death Ligand 1 in Fetomaternal Tolerance, Indira Guleria, Arezou Khosroshahi, Mohammed Javeed Ansari, Antje Habicht, Miyuki Azuma, Hideo Yagita, and Randolph J. Noelle

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Yos1p is a Novel Subunit of the Yip1p–Yif1p Complex and is Required for Transport between the Endoplasmic Reticulum and the Golgi Complex, Matthew Heidtman, Catherine Z. Chen, Ruth N. Collins, and Charles Barlowe

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The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA Binding, Marta Hristova, Darcy Birse, Yang Hong, and Victor Ambros

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Rat/MgrA, a Regulator of Autolysis, Is a Regulator of Virulence Genes in Staphylococcus aureus, Susham Ingavale, Willem van Wamel, Thanh T. Luong, Chia Y. Lee, and Ambrose L. Cheung

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Susceptibility of Biofilms to Bdellovibrio Bacteriovorus Attack, Daniel Kadouri and George A. O'Toole

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Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles, Barbara C. Kahl, Gunnar Belling, Petra Becker, Indranil Chatterjee, Katrin Wardecki, Karin Hilgert, and Ambrose Cheung

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Erythroid Cell-Specific α-Globin Gene Regulation by the CP2 Transcription Factor Family, Ho C. Kang, Jui Hyung Chae, Yeon H. Lee, Mi-Ae Park, June Ho Shin, Sung-Hyun Kim, Sang-Kyu Ye, Yoon Shin Cho, Steven Fiering, and Chul Geun Kim

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Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection, Michelle N. Kelly, Jay K. Kolls, Kyle Happel, and Joseph D. Schwartzman

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Composite Genome Map and Recombination Parameters Derived from Three Archetypal Lineages of Toxoplasma gondii, Asis Khan, Sonya Taylor, Chunlei Su, Aaron J. Mackey, Jon Boyle, Robert Cole, Darius Glover, Keliang Tang, Ian T. Paulsen, Matt Berriman, John C. Boothroyd, Elmer K. Pfefferkorn, J P. Dubey, James W. Ajioka, David S. Roos, John C. Wootton, and David Sibley

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TcpF Is a Soluble Colonization Factor and Protective Antigen Secreted by El Tor and Classical O1 and O139 Vibrio cholerae Serogroups, Thomas J. Kirn and Ronald K. Taylor

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A Three-Component Regulatory System Regulates Biofilm Maturation and Type III Secretion in Pseudomonas aeruginosa, Sherry l. Kuchma, John P. Connolly, and George A. O'Toole

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Silencing of Retrotransposons in Dictyostelium by DNA Methylation and RNAi, Markus Kuhlmann, Branimira E. Borisova, Markus Kaller, Pontus Larsson, Dirk Stach, Jianbo Na, Ludwig Eichinger, Frank Lyko, Victor Ambros, Fredrik Soderbom, Christian Hammann, and Wolfgang Nellen

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Identification of RecQL1 as a Holliday Junction Processing Enzyme in Human Cell Lines, Gary LeRoy, Robert Carroll, Saw Kyin, Masayuki Seki, and Michael D. Cole

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A Drosophila DEG/ENaC Channel Subunit is Required for Male Response to Female Pheromones, Heping Lin, Kevin J. Mann, Elena Starostina, Ronald D. Kinser, and Claudio W. Pikielny

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Requirements for Vibrio cholerae HapR Binding and Transcriptional Repression at the hapR Promoter Are Distinct from Those at the aphA Promoter, Wei Lin, Gabriela Kovacikova, and Karen Skorupski

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Principal Component Analysis for Predicting Transcription-Factor Binding Motifs from Array-Derived Data, Yunlong Liu, Matthew P Vincenti, and Hiroki Yokota

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Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice, Fangli Lu, Shiguang Huang, Mark S. Hu, and Lloyd H. Kasper

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Arsenite Regulates Cystic Fibrosis Transmem­brane Conductance Regulator and P-glycoprotein: Evidence of Pathway Independence, Rangan Maitra and Joshua Hamilton

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Dynamic Changes in Mcl-1 Expression Regulate Macrophage Viability or Commitment to Apoptosis during Bacterial Clearance, Helen M. Marriott, Colin D. Bingle, Robert C. Read, Karen E. Braley, Guido Kroemer, Paul G. Hellewell, Ruth W. Craig, Moira K.B. Whyte, and David H. Dockrell

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From the Cover: Assignment of an Essential Role for the Neurospora Frequency Gene in Circadian Entrainment to Temperature Cycles, Antonio M. Pregueiro, Nathan Price-Lloyd, Deborah Bell-Pedersen, Christian Heintzen, Jennifer J. Loros, and Jay C. Dunlap

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Automated Migration Analysis Based on Cell Texture: Method & Reliability, Jianfeng Qin, Thomas W. Chittenden, Ling Gao, and Justin D D. Pearlman

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Donepezil Effects on Mood in Patients with Schizophrenia and Schizoaffective Disorder, S Craig Risch, Michael D. Horner, Susan R. McGurk, Simmy Palecko, John S. Markowitz, Ziad Nahas, and C. Lindsay DeVane

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The Relationship Between FRQ-Protein Stability and Temperature Compensation in the Neurospora Circadian Clock, Peter Ruoff, Jennifer J. Loros, and Jay C. Dunlap

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Heparin Stimulates Staphylococcus aureus Biofilm Formation, Robert M. Q. Shanks, Niles P. Donegan, Martha L. Graber, Sarah E. Buckingham, Michael Zegans, Ambrose Cheung, and George A. O'Toole

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The CNS Role of Toll-Like Receptor 4 in Innate Neuroimmunity and Painful Neuropathy, Flobert Y. Tanga, Nancy Nutile-McMenemy, and Joyce A. DeLeo

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SarA Is an Essential Positive Regulator of Staphylococcus epidermidis Biofilm Development, Maria A. Tormo, Miguel Marti, Jaione Valle, and Adhar C. Manna

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SarA Positively Controls Bap-Dependent Biofilm Formation in Staphylococcus aureus, María P. Trotonda, Adhar C. Manna, Ambrose L. Cheung, Iñigo Lasa, and José R. Penadés

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Human Immunodeficiency Virus Type 1-Induced Macrophage Gene Expression Includes the p21 Gene, a Target for Viral Regulation, Nancy Vazquez, Teresa Greenwell-Wild, Nancy J. Marinos, William D. Swaim, Salvador Nares, David E. Ott, Ulrich Schubert, Peter Henklein, Jan M. Orenstein, Michael B. Sporn, and Sharon M. Wahl

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Embryonic Stem Cell-Derived Hematopoietic Stem Cells, Yuan Wang, Frank Yates, Olaia Naveiras, Patricia Ernst, and George Q. Daley

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Patient Characteristics and Clinical Management of Patients with Shoulder Pain in U.S. Primary Care Settings: Secondary Data Analysis of the National Ambulatory Medical Care Survey, James L. Wofford, Richard J. Mansfield, and Raquel S. Watkins

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Endothelial Nitric Oxide Synthase is Critical for Ischemic Remodeling, Mural Cell Recruitment, and Blood Flow Reserve, Jun Yu, Ebu D. deMuinck, Zhenwu Zhuang, and Mary Drinane

Submissions from 2004

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Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN, Cory L. Ahonen, Christie L. Doxsee, Sean M. M. McGurran, Tony R. Riter, William F. Wade, Richard J. Barth, John P. Vasilakos, Randolph J. Noelle, and Ross M. Kedl

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The Major Subunit of the Toxin-Coregulated Pilus TcpA Induces Mucosal and Systemic Immunoglobulin A Immune Responses in Patients with Cholera Caused by Vibrio cholerae O1 and O139, Muhammad Asaduzzaman, Edward T. Ryan, Manohar John, Long Hang, Ashraful I. Khan, A. S. G. Faruque, and Ronald K. Taylor

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An Intramolecular Association between Two Domains of the Protein Kinase Fused Is Necessary for Hedgehog Signaling, Manuel Ascano Jr. and David J. Robbins

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Chemical Genomics in Yeast, Charles Brenner

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A Double-Edged Sword: Globalization and Biosecurity, Stephen G. Brooks and Kendall Hoyt

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Isolation and Characterization of a Generalized Transducing Phage for Pseudomonas aeruginosa Strains PAO1 and PA14, Jonathan M. Budzik, William A. Rosche, Arne Rietsch, and George A. O'Toole

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SadB Is Required for the Transition from Reversible to Irreversible Attachment during Biofilm Formation by Pseudomonas aeruginosa PA14, Nicky C. Caiazza and George A. O'Toole

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Anemia and Blood Transfusion in the Critically Ill Patient: Role of Erythropoietin, Howard L. Corwin

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Effect of Escherichia Coli and Lactobacillus Rhamnosus on Macrophage Inflammatory Protein 3α, Tumor Necrosis Factor Alpha, and Transforming Growth Factor Β Release by Polarized Rat Uterine Epithelial Cells in Culture, M. A. Crane-Godreau and C. R. Wira

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Re-Engineering Systems for the Treatment of Depression in Primary Care: Cluster Randomised Controlled Trial, A. J. Dietrich, Thomas E. Oxman, John W. Williams Jr., Herbert C. Schulberg, Martha L. Bruce, Pamela W. Lee, and Sheila Barry

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Interdependent Assembly of Specific Regulatory Lipids and Membrane Fusion Proteins into the Vertex Ring Domain of Docked Vacuoles, Rutilio A. Fratti, Youngsoo Jun, Alexey J. Merz, Nathan Margolis, and William Wickner

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The KinI kinesin Kif2a is required for Bipolar Spindle Assembly through a Functional Relationship with MCAK, Neil J. Ganem and Duane A. Compton

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Role of a Cytotoxic-T-Lymphocyte Epitope-Defined, Alternative gag Open Reading Frame in the Pathogenesis of a Murine Retrovirus-Induced Immunodeficiency Syndrome, Arti Gaur and William R. Green

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CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency, Kathy A. Green, Cory L. Ahonen, W. James Cook, and William R. Green

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Phylogenetic Analysis of the Formin Homology 2 Domain, Henry N. Higgs and Kevin J. Peterson

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The Caenorhabditis Elegans F-Box Protein SEL-10 Promotes Female Development and May Target FEM-1 and FEM-3 for Degradation by the Proteasome, Sibylle Jager, Hillel T. Schwartz, H. Robert Horvitz, and Barbara Conradt

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Multiple Mechanisms Regulate NuMA Dynamics at Spindle Poles, Olga Kisurina-Evgenieva, Gary Mack, Quansheng Du, Ian Macara, Alexey Khodjakov, and Duane A. Compton

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Update on Diabetes Mellitus, Murray Korc

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Immune Responses of Different Mouse Strains after Challenge with Equivalent Lethal Doses of Toxoplasma Gondii, Y. H. Lee and L. H. Kasper

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Probabilistic Disease Classification of Expression-Dependent Proteomic Data from Mass Spectrometry of Human Serum, Ryan H. Lilien, Hany Farid, and Bruce R. Donald

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CD4+ T Cells in the Pathogenesis of Murine Ocular Toxoplasmosis, Fangli Lu, Shiguang Huang, and Lloyd H. Kasper

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Identification of sarV (SA2062), a New Transcriptional Regulator, Is Repressed by SarA and MgrA (SA0641) and Involved in the Regulation of Autolysis in Staphylococcus aureus, Adhar C. Manna, Susham S. Ingavale, MaryBeth Maloney, Willem van Wamel, and Ambrose L. Cheung