This collection contains works by faculty from the Thayer School of Engineering.

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Submissions from 2017

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Preclinical Evaluation of Spatial Frequency Domain-Enabled Wide-Field Quantitative Imaging for Enhanced Glioma Resection, Mira Sibai, Carl Fisher, Israel Veilleux, Jonathan T. Elliot, Frederic Leblond, David W. Roberts, and Brian Wilson

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A numerical framework for interstitial fluid pressure imaging in poroelastic MRE, Likun Tan, Matthew McGarry, Elijah E. W. Van Houten, and Ming Ji

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A Hybrid Dynamic System Assessment Methodology for Multi-Modal Transportation-Electrification, Thomas J.T van der Wardt and Amro M. Farid

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Both adhE and a Separate NADPH-Dependent Alcohol Dehydrogenase Gene, adhA, Are Necessary for High Ethanol Production in Thermoanaerobacterium saccharolyticum, Tianyong Zheng, Daniel G. Olson, Sean J. Murphy, Xiongjun Shao, Liang Tian, and Lee Lynd

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Neurologic Correlates of Gait Abnormalities in Cerebral Palsy: Implications for Treatment, Joanne Zhou, Erin E. Butler, and Jessica Rose

Submissions from 2016

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Polyfunctional Hiv-Specific Antibody Responses Are Associated with Spontaneous Hiv Control, Margaret E. Ackerman, Anastassia Mikhailova, Eric P. Brown, Karen G. Dowell, Bruce D. Walker, Chris Bailey-Kellogg, Todd J. Suscovich, and Galit Alter

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Quantum Random Number Generation Using a Quanta Image Sensor, Emna Amri, Yacine Felk, Damien Stucki, Jiaju Ma, and Eric Fossum

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Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses, Austin W. Boesch, Nana Yaw Osei-Owusu, Andrew R. Crowley, Thach H. Chu, Ying Chan, Joshua Weiner, Pranay Bharadwaj, Rufus Hards, Mark Adamo, Scott Gerber, Sarah Cocklin, Joern Schmitz, Adam Miles, Joshua Eckman, Aaron J. Belli, Keith Reimann, and Margaret E. Ackerman

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Quantitative Multi-plexed Fluorescence Spectroscopy in the Presence of a Strong Fluorescent Marker, Jaime J. Bravo, Scott Davis, Keith D. Paulsen, David W. Roberts, and Stephen Kanick

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Mathematical model to interpret localized reflectance spectra measured in the presence of a strong fluorescence marker, Jamie J. Bravo, Scott C. Davis, David W. Roberts, Keith D. Paulsen, and Stephen Kanick

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Pattern Phase Transitions of Self-Propelled Particles: Gases, Crystals, Liquids, and Mills, Zhao Cheng, Zhiyong Chen, Tamás Vicsek, and Duxin Chen

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Mechanical Self-Assembly of a Strain-Engineered Flexible Layer: Wrinkling, Rolling, and Twisting, Zi Chen, Gaoshan Huang, Ian Trase, Xiaomin Han, and Yongfeng Mei

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Perceptions of the Feasibility and Practicalities of Text Messaging-Based Infectious Disease Surveillance: A Questionnaire Survey, Linh T. Dang, Nguyen C. Vu, Thiem D. Vu, and Spencer L. James

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Multi-agent fluorescence imaging for quantitative assessment of tumor biomarkers, Scott C. Davis

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Small-Animal Imaging Using Diffuse Fluorescence Tomography., Scott Davis and Kenneth M. Tichauer

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Mass density at geostationary orbit and apparent mass refilling, Richard Denton, Kazue Takahashi, Justice Amoh, and J. Singer

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Review of Fluorescence Guided Surgery Systems: Identification of Key Performance Capabilities Beyond Indocyanine Green Imaging, Alisha V. DSouza, Huiyun Lin, Eric R. Henderson, and Kimberley S. Samkoe

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Optical Tracer Size Differences Allow Quantitation of Active Pumping Rate Versus Stokes–Einstein Diffusion in Lymphatic Transport, Alisha V. DSouza, Kayla Marra, Jason R. Gunn, Kimberley S. Samkoe, and Brian W. Pogue

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Microdose Fluorescence Imaging of ABY-029 on an Operating Microscope Adapted by Custom Illumination and Imaging Modules, Jonathan T. Elliott, Alisha V. Dsouza, Kayla Marra, Brian W. Pogue, David Roberts, and Keith Paulsen

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Opportunities for Energy-Water Nexus Management in the Middle East & North Africa, Amro M. Farid, William N. Lubega, and William W. Hickman

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Multiobjective Guided Priors Improve the Accuracy of Near-Infrared Spectral Tomography for Breast Imaging, Jinchao Feng, Shudong Jiang, Junqing Xu, Yan Zhao, Brian W. Pogue, and Keith D. Paulsen

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The Quanta Image Sensor: Every Photon Counts, Eric Fossum, Jiaju Ma, Saleh Masoodian, Leo Anzagira, and Rachel Zizza

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Photon Counting Error Rates in Single-Bit and Multi-Bit Quanta Image Sensors, Eric R. Fossum

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Use of a Multiplex Transcript Method for Analysis of Pseudomonas Aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung, Alex H. Gifford, Sven D. Willger, Emily L. Dolben, Lisa A. Moulton, Dana Dorman, Heather Bean, Jane Hill, Thomas Hampton, Alix Ashare, and Deborah Hogan

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Reduction of CMOS Image Sensor Read Noise to Enable Photon Counting, Michael Guidash, Jiaju Ma, Thomas Vogelsang, and Jay Endsley

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Neuron Morphology Influences Axon Initial Segment Plasticity, Allan T. Gulledge and Jaime J. Bravo

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The effects of Ca++ on the strength of polycrystalline ice, Kevin Hammonds and Ian Baker

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Blinking Phase-Change Nanocapsules Enable Background-Free Ultrasound Imaging, Alexander S. Hannah, Geoffrey P. Luke, and Stanislav Y. Emelianov

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Strain And Bioprocess Improvement of a Thermophilic Anaerobe for the Production of Ethanol from Wood, Christopher D. Herring, William R. Kenealy, A Joe Shaw, Sean F. Covalla, and Daniel G. Olson

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Elevated MTSS1 Expression Associated with Metastasis and Poor Prognosis of Residual Hepatitis B-Related Hepatocellular Carcinoma, Xiu-Yan Huang, Zi-Li Huang, Bin Xu, and Zi Chen

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Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma (vol 35, 85, 2016), Xiu-Yan Huang, Zi-Li Huang, Bin Xu, Zi Chen, Thomas J. Re, Qi Zheng, Zhao-You Tang, and Xin-Yu Huang

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Raman Spectroscopy Detects Distant Invasive Brain Cancer Cells Centimeters beyond MRI Capability in Humans, Michael Jermyn, Joannie Desroches, Jeanne Mercier, and Karl St-Arnaud

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Critical dosimetry measures and surrogate tools that can facilitate clinical success in PDT, Stephen Kanick, Brian Pogue, Scott Davis, Edward Maytin, Stephen P. Pereira, Akilan Palanisami, and Tayyaba Hasan

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Multi-spectral wide-field imaging for PplX PDT dosimetry of skin, Ethan LaRochelle, Hayden H. Chun, Tayyaba Hasan, Brian W. Pogue, Edward Maytin, Michael Chapman, and Scott Davis

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Trade-offs Between Three Forest Ecosystem Services Across the State of New Hampshire, USA: Timber, Carbon, and Albedo, David A. Lutz, Elizabeth A. Burakowski, Mackenzie B. Murphy, and Mark E. Borsuk

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Characterization and standardization of tissue-simulating protoporphyrin IX optical phantoms, Mikael Marois, Jamie J. Bravo, Scott Davis, and Stephen Kanick

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Effects of Breast Density and Compression on Normal Breast Tissue Hemodynamics through Breast Tomosynthesis Guided Near-Infrared Spectral Tomography, Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Brian W. Pogue, Keith D. Paulsen, and Steven P. Poplack

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Synchrotron X-ray fluorescence spectroscopy of salts in natural sea ice, Rachel W. Obbard, Ross M. Lieb-Lappen, Katherine V. Nordick, Ellyn J. Golden, Jeremiah R. Leonard, Antonio Lanzirotti, and Mathew G. Newville

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Biological Lignocellulose Solubilization: Comparative Evaluation of Biocatalysts and Enhancement Via Cotreatment, Julie M. D. Paye, Anna Guseva, Sarah K. Hammer, and Erica Gjersing

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Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success, Brian Pogue, Jonathon T. Elliot, Stephen Kanick, Scott Davis, and Kimberly Samkoe

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Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer, Ana Luiza Ribeiro de Souza, Kayla Marra, Jason Gunn, Kimberly Samkoe, Stephen Kanick, Scott Davis, M Shane Chapman, Edward Maytin, Tayyaba Hasan, and Brian Pogue

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A Markerless Gene Deletion and Integration System for Thermoanaerobacter Ethanolicus, Xiongjun Shao, Jilai Zhou, Daniel G. Olson, and Lee R. Lynd

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Potential of sugarcane in Modern energy Development in southern africa, Simone P. Souza, Luiz A Horta Nogueira, Helen K. Watson, and Lee R. Lynd

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Determining Conversion Gain and Read Noise Using a Photon-Counting Histogram Method for Deep Sub-Electron Read Noise Image Sensors, Dakota A. Starkey and Eric R. Fossum

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Improving Structure MCMC for Bayesian Networks through Markov Blanket Resampling, Chengwei Su and Mark E. Borsuk

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Simultaneous Achievement of High Ethanol Yield and Titer in Clostridium Thermocellum, Liang Tian, Beth Papanek, Daniel G. Olson, Thomas Rydzak, Evert K. Holwerda, Tianyong Zheng, Jilai Zhou, Marybeth Maloney, Nannan Jiang, Richard J. Giannone, Robert L. Hettich, Adam M. Guss, and Lee R. Lynd

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Design of Nanoparticle-Based Carriers for Targeted Drug Delivery, Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, and Zi Chen

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Portable, Parallel 9-Wavelength Near-Infrared Spectral Tomography (NIRST) System for Efficient Characterization of Breast Cancer within the Clinical Oncology Infusion Suite, Yan Zhao, Brian W. Pogue, Steffen J. Haider, Jiang Gui, Roberta diFlorio-Alexander, Keith Paulsen, and Shudong Jiang

Submissions from 2015

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Elimination of Hydrogenase Active Site Assembly Blocks H2 Production and Increases Ethanol Yield in Clostridium Thermocellum, Ranjita Biswas, Tianyong Zheng, Daniel G. Olson, Lee R. Lynd, and Adam M. Guss

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Structure-Based Redesign of Lysostaphin Yields Potent Antistaphylococcal Enzymes that Evade Immune Cell Surveillance, Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi, Wen Li, Regina S. Salvat, Daniel C. Osipovitch, Jennifer Fields, Leonard Moise, Brent L. Berwin, Steven N. Fiering, Chris Bailey-Kellogg, and Karl E. Griswold

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Method for accurate quantitation of background tissue optical properties in the presence of emission from a strong fluorescence marker, Jamie J. Bravo, Scott Davis, David W. Roberts, Keith D. Paulsen, and Stephen Kanick

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Microscale Magnetic Field Modulation for Enhanced Capture and Distribution of Rare Circulating Tumor Cells, Peng Chen, Yu-Yen Huang, Kazunori Hoshino, and John X.J Zhang

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Mice Null for the Deubiquitinase USP18 Spontaneously Develop Leiomyosarcomas, Fadzai Chinyengetere, David J. Sekula, Yun Lu, Andrew J. Giustini, Aarti Sanglikar, Masanori Kawakami, and Tian Ma

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Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees, Ickwon Choi, Amy W. Chung, Todd J. Suscovich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapha, Jaranit Kaewkungwal, Robert J. O'Connell, Donald Francis, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Galit Alter, Margaret E. Ackerman, and Chris Bailey-Kellogg

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Spectroscopic Separation of Čerenkov Radiation in High-Resolution Radiation Fiber Dosimeters, Arash Darafsheh, Rongxiao Zhang, Stephen Chad Kanick, Brian W. Pogue, and Jarod C. Finlay

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Next-Generation Raman tomography Instrument for Non-Invasive In Vivo Bone Imaging, Jennifer-Lynn H. Demers, Francis W. L. Esmonde-White, Karen A. Esmonde-White, Michael D. Morris, and Brian Pogue

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Logarithmic Intensity Compression in Fluorescence Guided Surgery Applications, Alisha V. DSouza, Huiyun Lin, Jason Gunn, and Brian W. Pogue

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Review of Fluorescence Guided Surgery Visualization and Overlay Techniques, Jonathan T. Elliott, Alisha V. Dsouza, Scott C. Davis, Jonathan D. Olson, Keith Paulsen, David Roberts, and Brian Pogue

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Does Material Choice Drive Sustainability of 3D Printing?, Jeremy Faludi, Zhongyin Hu, Shahd Alrashed, Christopher Braunholz, Suneesh Kaul, and Leulekal Kassaye

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Coculture of Staphylococcus aureus with Pseudomonas aeruginosa Drives S. aureus towards Fermentative Metabolism and Reduced Viability in a Cystic Fibrosis Model, Laura M. Filkins, Jyoti A. Graber, Daniel G. Olson, Emily L. Dolben, Lee Lynd, Sabin Bhuju, and George A. O'Toole

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Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies, Sebastian K. Grimm, Michael B. Battles, and Margaret E. Ackerman

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Dual-spacecraft Reconstruction of a Three-Dimensional Magnetic Flux Rope at the Earth's Magnetopause, H. Hasegawa, B. U. Ö. Sonnerup, S. Eriksson, and T. K. M. Nakamura

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Tomography of epidermal growth factor receptor binding to fluorescent Affibody in vivo studied with magnetic resonance guided fluorescence recovery in varying orthotopic glioma sizes, Robert W. Holt, Jennifer-Lynn H. Demers, Kristian Sexton, Jason Gunn, Scott Davis, Kimberly Samkoe, and Brian W. Pogue

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Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array, Yu-Yen Huang, Peng Chen, Chun-Hsien Wu, Kazunori Hoshino, Konstantin Sokolov, Nancy Lane, Huaying Liu, Michael Huebschman, Eugene Frenkel, and John X.J Zhang

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Improved Sensitivity to Fluorescence for Cancer Detection in Wide-Field Image-Guided Neurosurgery, Michael Jermyn, Yoann Gosselin, Pablo A. Valdes, Mira Sibai, and Kolbein Kolste

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Macroscopic-Imaging Technique for Subsurface Quantification of Near-Infrared Markers During Surgery, Michael Jermyn, Kolbein Kolste, Julien Pichette, Guillaume Sheehy, Leticia Angulo-Rodriguez, Keith D. Paulsen, David W. Roberts, Brian C. Wilson, Kevin Petrecca, and Frederic Leblond

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Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy, Stephen Kanick, Scott Davis, KL Sheehan, Yan Zhao, Tayyaba Hasan, Edward Maytin, Brian Pogue, and Michael Chapman

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Pre- treatment protoporphyrin IX concentration in actinic keratosis lesions predicts response to aminolevulinic-acid based photodynamic therapy, Stephen Kanick, Scott Davis, Yan Zhao, Tayyaba Hasan, and Edward Maytin

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Macroscopic Optical Imaging Technique for Wide-Field Estimation of Fluorescence Depth in Optically Turbid Media for Application in Brain Tumor Surgical Guidance, Kolbein K. Kolste, Stephen C. Kanick, Pablo A. Valdés, Michael Jermyn, Brian C. Wilson, David W. Roberts, Keith D. Paulsen, and Frederic Leblond

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The Role of Blowing Snow in the Activation of Bromine Over First-year Antarctic Sea Ice, R. M. Lieb-Lappen and R. W. Obbard

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The role of blowing snow in the activation of bromine over first-year Antarctic sea ice, Ross M. Lieb-Lappen and Rachel Obbard

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The Bifunctional Alcohol and Aldehyde Dehydrogenase Gene, adhE, Is Necessary for Ethanol Production in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum, Jonathan Lo, Tianyong Zheng, Shuen Hon, Daniel G. Olson, and Lee Lynd

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Deletion of nfnAB in Thermoanaerobacterium saccharolyticum and Its Effect on Metabolism, Jonathan Lo, Tianyong Zheng, Daniel G. Olson, Natalie Ruppertsberger, Shital Tripathi, Adam Guss, and Lee Lynd

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Framework for Hyperspectral Image Processing and Quantification for Cancer Detection During Animal Tumor Surgery, Guolan Lu, Dongsheng Wang, Xulei Qin, Luma Halig, Susan Muller, Hongzheng Zhang, Amy Chen, Brian W. Pogue, and Zhuo G. Chen

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Bioenergy and African Transformation, Lee R. Lynd, Mariam Sow, Annie Chimphango, Luis Cortez, Carlos H. Brito Cruz, Mosad Elmissiry, and Mark Laser

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Molecular Dyes used for Surgical Specimen Margin Orientation allow for Intraoperative Optical Assessment During Breast Conserving Surgery, David M. McClatchy, Venkataramanan Krishnaswamy, Stephen C. Kanick, Jonathan T. Elliott, Wendy A. Wells, Richard J. Barth Jr., Keith D. Paulsen, and Brian W. Pogue

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Calibration and Optimization of 3D Digital Breast Tomosynthesis Guided Near Infrared Spectral Tomography, Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven Poplack, Andrew Karellas, Brian Pogue, and Keith Paulsen

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Tumor Cell Targeting by Iron Oxide Nanoparticles is Dominated by Different Factors In Vitro versus In Vivo, Christian NDong, Jennifer A. Tate, Warren C. Kett, Jaya Batra, Eugene Demidenko, Lionel D. Lewis, P. Jack Hoopes, Tillmann U. Gerngross, and Karl E. Griswold

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Antibody-Mediated Targeting of Iron Oxide Nanoparticles to the Folate Receptor Alpha Increases Tumor Cell Association In Vitro and In Vivo, Christian Ndong, Seiko Toraya-Brown, Katsiaryna Kekalo, Ian Baker, Tillman U. Gerngross, Steven N. Fiering, and Karl E. Griswold

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X-ray computed microtomography of sea ice - comment on "A review of air-ice chemical and physical interactions (AICI): liquids, quasi-liquids, and solids in snow" by Bartels-Rausch et al. (2014), Rachel Obbard

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GPS Phase Scintillation at High Latitudes during Geomagnetic Storms of 7–17 March 2012 – Part 1: The North American Sector, P. Prikryl, R. Ghoddousi-Fard, E. G. Thomas, J. M. Ruohoniemi, and S. G. Shepherd

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Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate, Regina S. Salvat, Andrew S. Parker, Yoonjoo Choi, Chris Bailey-Kellogg, and Karl E. Griswold

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Winter Rye as a Bioenergy Feedstock: Impact of Crop Maturity on Composition, Biological Solubilization and Potential Revenue, Xiongjun Shao, Kay DiMarco, Tom L. Richard, and Lee R. Lynd

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Anaerobic Detoxification of Acetic Acid in a Thermophilic Ethanologen, A Joe Shaw, Bethany B. Miller, Stephen R. Rogers, William Robert Kenealy, Alex Meola, Ashwini Bhandiwad, W Ryan Sillers, Indraneel Shikhare, David Hogsett, and Christopher Herring

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Quantitative Spatial Frequency Fluorescence Imaging in the Sub-Diffusive Domain for Image-Guided Glioma Resection, Mira Sibai, Israel Veilleux, Jonathan T. Elliott, Frederic Leblond, and Brian Wilson

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The Role of Damage and Recrystallization in the Elastic Properties of Columnar Ice, Scott A. Snyder, Erland M. Schulson, and Carl E. Renshaw

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Modeling Neurovascular Coupling from Clustered Parameter Sets for Multimodal EEG-NIRS, M. Tanveer Talukdar, H. Robert Frost, and Solomon G. G. Diamond

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Review of Biomedical Čerenkov Luminescence Imaging Applications, Kaveh Tanha, Ali Mahmoud Pashazadeh, and Brian W. Pogue

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The Role of Visualization and 3-D Printing in Biological Data Mining, Talia L. Weiss, Amanda Zieselman, Douglas P. Hill, Solomon G. Diamond, Li Shen, Andrew J. Saykin, and Jason H. Moore

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Direct Regularization from Co-Registered Anatomical Images for MRI-Guided Near-Infrared Spectral Tomographic Image Reconstruction, Limin Zhang, Yan Zhao, Shudong Jiang, Brian W. Pogue, and Keith Paulsen

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Optimization of Image Reconstruction for Magnetic Resonance Imaging–Guided Near-Infrared Diffuse Optical Spectroscopy in Breast, Yan Zhao, Michael A. Mastanduno, Shudong Jiang, Fadi EI-Ghussein, Jiang Gui, Brian W. Pogue, and Keith D. Paulsen

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Cofactor Specificity of the Bifunctional Alcohol and Aldehyde Dehydrogenase (AdhE) in Wild-Type and Mutant Clostridium thermocellum and Thermoanaerobacterium saccharolyticum, Tianyong Zheng, Daniel G. Olson, Liang Tian, Yannick J. Bomble, Michael Himmel, Jonathan Lo, Shuen Hon, A. Joe Shaw, Johannes P. van Dijken, and Lee Lynd

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Physiological Roles of Pyruvate Ferredoxin Oxidoreductase and Pyruvate Formate-Lyase in Thermoanaerobacterium Saccharolyticum Jw/Sl-Ys485, Jilai Zhou, Daniel G. Olson, Anthony A. Lanahan, Liang Tian, Sean Jean-Loup Murphy, Jonathan Lo, and Lee R. Lynd

Submissions from 2014

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Gas Diffusivity and Permeability Through the Firn Column at Summit, Greenland: Measurements and Comparison to Microstructural Properties, A. C. C. Adolph and M. R. Albert

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Increase in Ethanol Yield via Elimination of Lactate Production in an Ethanol-Tolerant Mutant of Clostridium Thermocellum, Ranjita Biswas, Sandeep Prabhu, Lee R. Lynd, and Adam M. Guss

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An Autoreactive Antibody from an SLE/HIV-1 Individual Broadly Neutralizes HIV-1, Mattia Bonsignori, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, Abby J. Cooper, Kwan-Ki Hwang, Xi Chen, Mengfei Liu, Krisha McKee, Robert J. Parks, Joshua Eudailey, Minyue Wang, Megan Clowse, Lisa G. Criscione-Schreiber, M Anthony Moody, and Margaret E. Ackerman

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An Imaging-Based Platform for High-Content, Quantitative Evaluation of Therapeutic Response in 3d Tumour Models, Jonathan P. Celli, Imran Rizvi, Adam R. Blanden, Iqbal Massodi, Iqbal Massodi, Michael D. Glidden, Brian Pogue, and Tayyaba Hasan

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Microstructure and Magnetic Properties of Bulk Nanocrystalline MnAl, Anurag Chaturvedi, Rumana Yaqub, and Ian Baker

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Benthic and Pelagic Pathways of Methylmercury Bioaccumulation in Estuarine Food Webs of the Northeast United States, Celia Y. Chen, Mark E. Borsuk, Deenie M. Bugge, and Terill Hollweg

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Cryogenic EBSD reveals structure of directionally solidified ice-polymer composite, Amelia E. Donius, Rachel Obbard, Jonadan Ando Burger, and Philipp M. Hunger